Seroatlas · Human Serome Atlas

MATCAP1

Microtubule-associated tyrosine carboxypeptidase 1

Also known as: KIAA0895L, LOC653319, MACA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68EN5
Gene: MATCAP1
Ensembl: ENSG00000196123
Chromosome: 16
Canonical length: 471 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Enables tubulin-tyrosine carboxypeptidase. Predicted to be involved in brain development. Is active in microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

471 residues, UniProt reviewed canonical sequence.

>Q68EN5|MATCAP1
     1  MVLDSGAQAY DQAPPSPPTS PPSLRHRLKP SDRDGPPLYP WSQSLALPLA LAVPPALQPQ
    61  PEQQPFSQML LGHRGHMRRS ESTYSVNSTG RRGRGTLGRP PPGRGRNPGG GTLRPAASLP
   121  HIAKTQRDAG HIASKSPCML VALRPTNMDR ERDKFFQSHY TYNPQFEYQE PMPTAVLEKY
   181  CEASGQFIHQ AVGIIEAVLE KFGTYEHFEA ATGGQLLTKC QIWSIVRKYM QKEGCAGEVV
   241  VQLSEDLLSQ AVMMVENSRP TLAINLTGAR QYWLEGMLRH EIGTHYLRGV NNARQPWHNA
   301  EGRLRYGLRP ANPTEEGLAS LHSVLFRKQP FLWRAALLYY TIHRAARMSF RQLFQDLERY
   361  VQDADVRWEY CVRAKRGQTD TSLPGCFSKD QVYLDGIVRI LRHRQTIDFP LLTSLGKVSY
   421  EDVDHLRPHG VLDNTRVPHF MQDLARYRQQ LEHIMATNRL DEAELGRLLP D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MATCAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 79 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 79 nTPM
pituitary gland: 42 nTPM
ovary: 37 nTPM
fallopian tube: 33 nTPM
retina: 27 nTPM
cerebral cortex: 26 nTPM

Single-cell type

late spermatids: 361 nCPM
early spermatids: 121 nCPM
retinal horizontal cells: 80 nCPM
tuft cells: 58 nCPM
retinal ganglion cells: 54 nCPM
retinal bipolar cells: 52 nCPM

Immune cell

plasmacytoid DC: 0.5 nTPM
myeloid DC: 0.4 nTPM
intermediate monocyte: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

cerebellum: 37 nTPM
cerebral cortex: 30 nTPM
pons: 28 nTPM
hippocampal formation: 28 nTPM
white matter: 26 nTPM
basal ganglia: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

microtubule

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MATCAP1 as an antibody target. Whether an autoantibody or antibody against MATCAP1 could matter depends on whether native MATCAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MATCAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MATCAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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