Seroatlas · Human Serome Atlas

MAS1L

Mas-related G-protein coupled receptor MRG

Also known as: dJ994E9.2, MAS-L, MAS1L_HUMAN, MRG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P35410
Gene: MAS1L
Ensembl: ENSG00000204687
Chromosome: 6
Canonical length: 378 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>P35410|MAS1L
     1  MVWGKICWFS QRAGWTVFAE SQISLSCSLC LHSGDQEAQN PNLVSQLCGV FLQNETNETI
    61  HMQMSMAVGQ QALPLNIIAP KAVLVSLCGV LLNGTVFWLL CCGATNPYMV YILHLVAADV
   121  IYLCCSAVGF LQVTLLTYHG VVFFIPDFLA ILSPFSFEVC LCLLVAISTE RCVCVLFPIW
   181  YRCHRPKYTS NVVCTLIWGL PFCINIVKSL FLTYWKHVKA CVIFLKLSGL FHAILSLVMC
   241  VSSLTLLIRF LCCSQQQKAT RVYAVVQISA PMFLLWALPL SVAPLITDFK MFVTTSYLIS
   301  LFLIINSSAN PIIYFFVGSL RKKRLKESLR VILQRALADK PEVGRNKKAA GIDPMEQPHS
   361  TQHVENLLPR EHRVDVET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAS1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 2.9 nTPM

Expression across tissuesHPA

Tissue

cervix: 2.9 nTPM
epididymis: 1.8 nTPM
breast: 1.1 nTPM
esophagus: 1 nTPM
colon: 0.7 nTPM
endometrium: 0.6 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.21
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G protein-coupled receptor signaling pathway

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAS1L as an antibody target. Whether an autoantibody or antibody against MAS1L could matter depends on whether native MAS1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAS1L is annotated at the cell surface, where native MAS1L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MAS1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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