MAS1

Protein identityUniProt · HPA

UniProt accession

P04201

Gene

MAS1

Ensembl

ENSG00000130368

Chromosome

6

Canonical length

325 aa

Protein class

Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>P04201|MAS1
     1  MDGSNVTSFV VEEPTNISTG RNASVGNAHR QIPIVHWVIM SISPVGFVEN GILLWFLCFR
    61  MRRNPFTVYI THLSIADISL LFCIFILSID YALDYELSSG HYYTIVTLSV TFLFGYNTGL
   121  YLLTAISVER CLSVLYPIWY RCHRPKYQSA LVCALLWALS CLVTTMEYVM CIDREEESHS
   181  RNDCRAVIIF IAILSFLVFT PLMLVSSTIL VVKIRKNTWA SHSSKLYIVI MVTIIIFLIF
   241  AMPMRLLYLL YYEYWSTFGN LHHISLLFST INSSANPFIY FFVGSSKKKR FKESLKVVLT
   301  RAFKDEMQPR RQKDNCNTVT VETVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

2 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.47

gnomAD pLI

0

gnomAD missense Z

-0.03

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating G protein-coupled receptor signaling pathway
• angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure
• G protein-coupled receptor signaling pathway
• phospholipase C-activating angiotensin-activated signaling pathway
• positive regulation of canonical NF-kappaB signal transduction
• regulation of inflammatory response

Molecular functions

• angiotensin type II receptor activity
• G protein-coupled receptor activity
• peptide binding
• angiotensin receptor activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• GPCR, rhodopsin-like, 7TM
• Mas-related G protein-coupled receptor family
• 7 transmembrane receptor (rhodopsin family)
• Proto-oncogene Mas

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Proto-oncogene
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MAS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AGTR1
• FLNA