Seroatlas · Human Serome Atlas

MARVELD3

MARVEL domain-containing protein 3

Also known as: MALD3_HUMAN, MRVLDC3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A59
Gene: MARVELD3
Ensembl: ENSG00000140832
Chromosome: 16
Canonical length: 401 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles,Intermediate filaments

OverviewNCBI Gene

Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in bicellular tight junction assembly. Acts upstream of or within several processes, including negative regulation of JNK cascade; negative regulation of epithelial cell migration; and protein localization to cell junction. Located in bicellular tight junction and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

401 residues, UniProt reviewed canonical sequence.

>Q96A59|MARVELD3
     1  MEDPSGAREP RARPRERDPG RRPHPDQGRT HDRPRDRPGD PRRKRSSDGN RRRDGDRDPE
    61  RDQERDGNRD RNRDRERERE RERDPDRGPR RDTHRDAGPR AGEHGVWEKP RQSRTRDGAR
   121  GLTWDAAAPP GPAPWEAPEP PQPQRKGDPG RRRPESEPPS ERYLPSTPRP GREEVEYYQS
   181  EAEGLLECHK CKYLCTGRAC CQMLEVLLNL LILACSSVSY SSTGGYTGIT SLGGIYYYQF
   241  GGAYSGFDGA DGEKAQQLDV QFYQLKLPMV TVAMACSGAL TALCCLFVAM GVLRVPWHCP
   301  LLLVTEGLLD MLIAGGYIPA LYFYFHYLSA AYGSPVCKER QALYQSKGYS GFGCSFHGAD
   361  IGAGIFAALG IVVFALGAVL AIKGYRKVRK LKEKPAEMFE F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MARVELD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

small intestine: 31 nTPM
duodenum: 29 nTPM
colon: 21 nTPM
rectum: 17 nTPM
pancreas: 16 nTPM
parathyroid gland: 12 nTPM

Single-cell type

enterocytes: 274 nCPM
colonocytes: 152 nCPM
goblet cells: 92 nCPM
enteric transient amplifying cells: 75 nCPM
tuft cells: 69 nCPM
enteric stem cells: 69 nCPM

Immune cell

basophil: 1.5 nTPM
neutrophil: 1 nTPM
NK-cell: 0.4 nTPM
naive B-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
classical monocyte: 0.2 nTPM

Brain region

choroid plexus: 17 nTPM
cerebellum: 7.2 nTPM
hippocampal formation: 5.8 nTPM
cerebral cortex: 5.4 nTPM
white matter: 5.4 nTPM
hypothalamus: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

mitogen-activated protein kinase kinase kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Marvel domain
MARVEL domain-containing protein 3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MARVELD3 as an antibody target. Whether an autoantibody or antibody against MARVELD3 could matter depends on whether native MARVELD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MARVELD3 is annotated at the cell surface, where native MARVELD3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MARVELD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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