Seroatlas · Human Serome Atlas

MARVELD1

MARVEL domain-containing protein 1

Also known as: bA548K23.8, FLJ22343, FLJ23440, GB14, MALD1_HUMAN, MGC4415, MRVLDC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSK0
Gene: MARVELD1
Ensembl: ENSG00000155254
Chromosome: 10
Canonical length: 173 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to be located in several cellular components, including cytoskeleton; nucleus; and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

173 residues, UniProt reviewed canonical sequence.

>Q9BSK0|MARVELD1
     1  MLPPPPRQPP PQARAARGAV RLQRPFLRSP LGVLRLLQLL AGAAFWITIA TSKYQGPVHF
    61  ALFVSVLFWL LTLGLYFLTL LGKHELVPVL GSRWLMVNVA HDVLAAALYG AATGIMSDQM
   121  QRHSYCNLKD YPLPCAYHAF LAAAVCGGVC HGLYLLSALY GCGRRCQGKQ EVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MARVELD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 100 nTPM
cervix: 58 nTPM
endometrium: 57 nTPM
colon: 55 nTPM
fallopian tube: 51 nTPM
seminal vesicle: 46 nTPM

Single-cell type

schwann cells: 65 nCPM
breast myoepithelial cells: 61 nCPM
hepatic stellate cells: 52 nCPM
bergmann glia: 51 nCPM
peritubular myoid cells: 44 nCPM
vascular smooth muscle cells: 42 nCPM

Immune cell

classical monocyte: 3.2 nTPM
myeloid DC: 3.1 nTPM
intermediate monocyte: 2.7 nTPM
total PBMC: 1 nTPM
plasmacytoid DC: 0.8 nTPM
non-classical monocyte: 0.7 nTPM

Brain region

choroid plexus: 51 nTPM
hypothalamus: 13 nTPM
medulla oblongata: 11 nTPM
thalamus: 11 nTPM
white matter: 10 nTPM
spinal cord: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.36
gnomAD missense Z: 1.21

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

myelination

Molecular functions

structural constituent of myelin sheath

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MARVELD1 as an antibody target. Whether an autoantibody or antibody against MARVELD1 could matter depends on whether native MARVELD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MARVELD1 is annotated at the cell surface, where native MARVELD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MARVELD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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