Seroatlas · Human Serome Atlas

MARCKSL1

MARCKS-related protein

Also known as: F52, MacMARCKS, MLP, MLP1, MRP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P49006
Gene: MARCKSL1
Ensembl: ENSG00000175130
Chromosome: 1
Canonical length: 195 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Actin filaments,Cytosol

OverviewNCBI Gene

This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>P49006|MARCKSL1
     1  MGSQSSKAPR GDVTAEEAAG ASPAKANGQE NGHVKSNGDL SPKGEGESPP VNGTDEAAGA
    61  TGDAIEPAPP SQGAEAKGEV PPKETPKKKK KFSFKKPFKL SGLSFKRNRK EGGGDSSASS
   121  PTEEEQEQGE IGACSDEGTA QEGKAAATPE SQEPQAKGAE ASAASEEEAG PQATEPSTPS
   181  GPESGPTPAS AEQNE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MARCKSL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 1,098 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 1,098 nTPM
midbrain: 535 nTPM
hippocampal formation: 391 nTPM
ovary: 378 nTPM
amygdala: 365 nTPM
hypothalamus: 301 nTPM

Single-cell type

tuft cells: 1,026 nCPM
granulosa cells: 863 nCPM
breast secretory cells: 628 nCPM
ovarian stromal cells: 606 nCPM
enteric stem cells: 559 nCPM
peritubular myoid cells: 535 nCPM

Immune cell

eosinophil: 253 nTPM
non-classical monocyte: 30 nTPM
naive B-cell: 28 nTPM
intermediate monocyte: 23 nTPM
memory B-cell: 20 nTPM
neutrophil: 18 nTPM

Brain region

white matter: 1,075 nTPM
medulla oblongata: 954 nTPM
cerebellum: 761 nTPM
pons: 723 nTPM
midbrain: 682 nTPM
basal ganglia: 681 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0.01
gnomAD missense Z: -0.19
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MARCKSL1 as an antibody target. Whether an autoantibody or antibody against MARCKSL1 could matter depends on whether native MARCKSL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MARCKSL1 is annotated at the cell surface, where native MARCKSL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MARCKSL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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