Seroatlas · Human Serome Atlas

MAP9

Microtubule-associated protein 9

Also known as: ASAP, FLJ21159, MAP9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q49MG5
Gene
MAP9
Ensembl
ENSG00000164114
Chromosome
4
Canonical length
647 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Primary cilium,Primary cilium transition zone,Centrosome

OverviewNCBI Gene

ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin et al., 2005 [PubMed 16049101]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

647 residues, UniProt reviewed canonical sequence.

>Q49MG5|MAP9
     1  MSDEVFSTTL AYTKSPKVTK RTTFQDELIR AITARSARQR SSEYSDDFDS DEIVSLGDFS
    61  DTSADENSVN KKMNDFHISD DEEKNPSKLL FLKTNKSNGN ITKDEPVCAI KNEEEMAPDG
   121  CEDIVVKSFS ESQNKDEEFE KDKIKMKPKP RILSIKSTSS AENNSLDTDD HFKPSPRPRS
   181  MLKKKSHMEE KDGLEDKETA LSEELELHSA PSSLPTPNGI QLEAEKKAFS ENLDPEDSCL
   241  TSLASSSLKQ ILGDSFSPGS EGNASGKDPN EEITENHNSL KSDENKENSF SADHVTTAVE
   301  KSKESQVTAD DLEEEKAKAE LIMDDDRTVD PLLSKSQSIL ISTSATASSK KTIEDRNIKN
   361  KKSTNNRASS ASARLMTSEF LKKSSSKRRT PSTTTSSHYL GTLKVLDQKP SQKQSIEPDR
   421  ADNIRAAVYQ EWLEKKNVYL HEMHRIKRIE SENLRIQNEQ KKAAKREEAL ASFEAWKAMK
   481  EKEAKKIAAK KRLEEKNKKK TEEENAARKG EALQAFEKWK EKKMEYLKEK NRKEREYERA
   541  KKQKEEETVA EKKKDNLTAV EKWNEKKEAF FKQKEKEKIN EKRKEELKRA EKKDKDKQAI
   601  NEYEKWLENK EKQERIERKQ KKRHSFLESE ALPPWSPPSR TVFAKVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 32 nTPM
  • choroid plexus: 20 nTPM
  • cerebral cortex: 16 nTPM
  • retina: 15 nTPM
  • thyroid gland: 15 nTPM
  • testis: 12 nTPM

Single-cell type

  • respiratory ciliated cells: 237 nCPM
  • fallopian tube ciliated cells: 219 nCPM
  • endometrial ciliated cells: 132 nCPM
  • corticotrophs: 121 nCPM
  • epididymal efferent duct ciliated cells: 118 nCPM
  • gonadotrophs: 106 nCPM

Immune cell

  • naive B-cell: 4.8 nTPM
  • memory B-cell: 2.9 nTPM
  • gdT-cell: 2.7 nTPM
  • plasmacytoid DC: 2.6 nTPM
  • memory CD8 T-cell: 2.5 nTPM
  • MAIT T-cell: 2.1 nTPM

Brain region

  • cerebral cortex: 75 nTPM
  • hypothalamus: 67 nTPM
  • pons: 59 nTPM
  • medulla oblongata: 55 nTPM
  • thalamus: 53 nTPM
  • cerebellum: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
0.16
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Microtubule-associated protein 9

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP9 as an antibody target. Whether an autoantibody or antibody against MAP9 could matter depends on whether native MAP9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAP9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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