Seroatlas · Human Serome Atlas

MAP7D3

MAP7 domain-containing protein 3

Also known as: FLJ12649, MA7D3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWC1
Gene: MAP7D3
Ensembl: ENSG00000129680
Chromosome: X
Canonical length: 876 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Primary cilium,Centrosome,Basal body

OverviewNCBI Gene

The protein encoded by this gene belongs to the MAP7 (microtubule-associated protein 7) family. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

876 residues, UniProt reviewed canonical sequence.

>Q8IWC1|MAP7D3
     1  MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI RSTFKPVIDG
    61  SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL QYEKQMEERQ RKLKERKEKE
   121  EQRRIAAEEK RHQKDEAQKE KFTAILYRTL ERRRLADDYQ QKRWSWGGSA MANSESKTAN
   181  KRSASTEKLE QGTSALIRQM PLSSAGLQNS VAKRKTDKER SSSLNRRDSN LHSSTDKEQA
   241  ERKPRVTGVT NYVMQYVTVP LRKCTSDELR AVMFPMSTMK IPPQTKVEES PLEKVETPPK
   301  ASVDAPPQVN VEVFCNTSME ASPKAGVGMA PEVSTDSFPV VSVDVSPVVS TYDSEMSMDA
   361  SPELSIEALP KVDLETVPKV SIVASPEASL EAPPEVSLEA LPEVSVEAAP EGSLEAPPKG
   421  SAEVAPKESV KGSPKESMEA SPEAMVKASP KTSLEASMEA SPKAKARDAP KKSEMDKQAL
   481  IPIAKKRLSS YTECYKWSSS PENACGLPSP ISTNRQIQKN CPPSPLPLIS KQSPQTSFPY
   541  KIMPIQHTLS VQSASSTVKK KKETVSKTTN RCEALSQRHM IYEESGNKST AGIMNAEAAT
   601  KILTELRRLA REQREKEEEE RQREEMQQRV IKKSKDMAKE AVGGQAEDHL KLKDGQQQNE
   661  TKKKKGWLDQ EDQEAPLQKG DAKIKAQEEA DKRKKEHERI MLQNLQERLE RKKRIEEIMK
   721  RTRKTDVNAS KVTETSSHDI YEEAEADNEE SDKDSLNEMF PSAILNGTGS PTKFKMPFNN
   781  AKKMTHKLVF LEDGTSQVRK EPKTYFNGDL KNFRQKSMKD TSIQEVVSRP SSKRMTSHTT
   841  KTRKADETNT TSRSSAQTKS EGFHDILPKS SDTFRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP7D3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 28 nTPM
adipose tissue: 17 nTPM
ovary: 15 nTPM
testis: 15 nTPM
fallopian tube: 14 nTPM
breast: 11 nTPM

Single-cell type

late spermatids: 281 nCPM
early spermatids: 191 nCPM
extravillous trophoblasts: 159 nCPM
oocytes: 143 nCPM
differentiating spermatogonia: 128 nCPM
late primary spermatocytes: 127 nCPM

Immune cell

non-classical monocyte: 8 nTPM
memory B-cell: 7.5 nTPM
NK-cell: 6.6 nTPM
basophil: 6.5 nTPM
MAIT T-cell: 6.5 nTPM
naive B-cell: 6.4 nTPM

Brain region

choroid plexus: 7.1 nTPM
medulla oblongata: 5.1 nTPM
white matter: 5 nTPM
thalamus: 4.7 nTPM
hypothalamus: 4.6 nTPM
pons: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP7D3 as an antibody target. Whether an autoantibody or antibody against MAP7D3 could matter depends on whether native MAP7D3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP7D3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP7D3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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