Seroatlas · Human Serome Atlas

MAP7D2

MAP7 domain-containing protein 2

Also known as: FLJ14503, MA7D2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96T17
Gene: MAP7D2
Ensembl: ENSG00000184368
Chromosome: X
Canonical length: 732 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable kinesin binding activity and microtubule binding activity. Predicted to be involved in axon development and microtubule cytoskeleton organization. Predicted to be located in axon; microtubule cytoskeleton; and midbody. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

732 residues, UniProt reviewed canonical sequence.

>Q96T17|MAP7D2
     1  MERGGGGSGT GSRPEGTARG TSLPGKIAEP GAVRTSQPNY RPQGMEGFLK SDERQRLAKE
    61  RREEREKCLA AREQQILEKQ KRARLQYEKQ MEERWRKLEE QRQREDQKRA AVEEKRKQKL
   121  REEEERLEAM MRRSLERTQQ LELKKKYSWG APLAIGPGGH DACDKLSTST MSLPKPTEPP
   181  MNKRLSSSTV AISYSPDRVF HVCPRLAPLG PLNPSYKSSP TRNIEKKKAT STSTSGAGDV
   241  GKEALSGGEA SLVEKVKRGQ RTATSLPVVN FGSPLRRCEF SGGIPKRPSS PVISKTATKA
   301  YPQSPKTTKP PYPGSPVKYR LPALSGQDMP KRKAEKEKSN KEREGTLAQQ AAGPQGEEAL
   361  EKHVVDKHAS EKHAAAAGGK AENSAALGKP TAGTTDAGEA AKILAEKRRQ ARLQKEQEEQ
   421  ERLEKEEQDR LEREELKRKA EEERLRLEEE ARKQEEERKR QEEEKKKQEG EEKRKAGEEA
   481  KRKAEEELLL KEKQEQEKQE KAMIEKQKEA AETKAREVAE QMRLEREQIM LQIEQERLER
   541  KKRIDEIMKR TRKSDVSPQV KKEDPKVGVQ PAVCVEKKTK LVVPNKMEIN GLNTCQEVNG
   601  VDHAAPETYP QDIFSNGLKP AGGLIHLDAL DGKSNSLDDS TEEVQSMDVS PVSKEELISI
   661  PEFSPVSEMI PGVSLDQNGT GNARALQDLL DFTGPPTFPK RSSENLSLDD CNKNLIEGFN
   721  SPGQETPLNT FC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP7D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

epididymis: 34 nTPM
cerebral cortex: 30 nTPM
cerebellum: 23 nTPM
basal ganglia: 21 nTPM
hypothalamus: 21 nTPM
hippocampal formation: 14 nTPM

Single-cell type

oocytes: 230 nCPM
differentiating spermatogonia: 208 nCPM
cytotrophoblasts: 162 nCPM
foveolar cells: 120 nCPM
early primary spermatocytes: 112 nCPM
undifferentiated spermatogonia: 112 nCPM

Immune cell

basophil: 3 nTPM
plasmacytoid DC: 0.3 nTPM
MAIT T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 171 nTPM
pons: 101 nTPM
medulla oblongata: 83 nTPM
white matter: 69 nTPM
thalamus: 63 nTPM
hypothalamus: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.04
gnomAD missense Z: -0.25
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAP7D2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP7D2 as an antibody target. Whether an autoantibody or antibody against MAP7D2 could matter depends on whether native MAP7D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP7D2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP7D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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