Seroatlas · Human Serome Atlas

MAP6D1

MAP6 domain-containing protein 1

Also known as: FLJ12748, MA6D1_HUMAN, SL21

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9H5
Gene: MAP6D1
Ensembl: ENSG00000180834
Chromosome: 3
Canonical length: 199 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a protein highly similar to the mouse MAP6 domain containing 1 protein, which is related to the STOP proteins. Based on the study of the mouse protein, the encoded protein may function as a calmodulin-regulated neuronal protein that binds and stabilizes microtubules but also associates with the Golgi membranes through N-terminal palmitoylation. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q9H9H5|MAP6D1
     1  MAWPCISRLC CLARRWNQLD RSDVAVPLTL HGYSDLDSEE PGTGGAASRR GQPPAGARDS
    61  GRDVPLTQYQ RDFGLWTTPA GPKDPPPGRG PGAGGRRGKS SAQSSAPPAP GARGVYVLPI
   121  GDADAAAAVT TSYRQEFQAW TGVKPSRSTK TKPARVITTH TSGWDSSPGA GFQVPEVRKK
   181  FTPNPSAIFQ ASAPRILNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP6D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 120 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 120 nTPM
cerebellum: 87 nTPM
midbrain: 54 nTPM
hippocampal formation: 50 nTPM
basal ganglia: 38 nTPM
cerebral cortex: 29 nTPM

Single-cell type

oligodendrocytes: 102 nCPM
brain excitatory neurons: 21 nCPM
oligodendrocyte progenitor cells: 7.6 nCPM
brain inhibitory neurons: 6.9 nCPM
other brain neurons: 6.3 nCPM
ependymal cells: 6.1 nCPM

Immune cell

memory CD8 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 170 nTPM
medulla oblongata: 102 nTPM
basal ganglia: 97 nTPM
cerebellum: 87 nTPM
midbrain: 84 nTPM
pons: 81 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0.11
gnomAD missense Z: -0.17
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Microtubule-associated protein 6

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP6D1 as an antibody target. Whether an autoantibody or antibody against MAP6D1 could matter depends on whether native MAP6D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP6D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP6D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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