Seroatlas · Human Serome Atlas

MAP3K6

Mitogen-activated protein kinase kinase kinase 6

Also known as: ASK2, M3K6_HUMAN, MAPKKK6, MEKK6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95382
Gene: MAP3K6
Ensembl: ENSG00000142733
Chromosome: 1
Canonical length: 1288 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

1288 residues, UniProt reviewed canonical sequence.

>O95382|MAP3K6
     1  MAGPCPRSGA ERAGSCWQDP LAVALSRGRQ LAAPPGRGCA RSRPLSVVYV LTREPQPGLE
    61  PREGTEAEPL PLRCLREACA QVPRPRPPPQ LRSLPFGTLE LGDTAALDAF YNADVVVLEV
   121  SSSLVQPSLF YHLGVRESFS MTNNVLLCSQ ADLPDLQALR EDVFQKNSDC VGSYTLIPYV
   181  VTATGRVLCG DAGLLRGLAD GLVQAGVGTE ALLTPLVGRL ARLLEATPTD SCGYFRETIR
   241  RDIRQARERF SGPQLRQELA RLQRRLDSVE LLSPDIIMNL LLSYRDVQDY SAIIELVETL
   301  QALPTCDVAE QHNVCFHYTF ALNRRNRPGD RAKALSVLLP LVQLEGSVAP DLYCMCGRIY
   361  KDMFFSSGFQ DAGHREQAYH WYRKAFDVEP SLHSGINAAV LLIAAGQHFE DSKELRLIGM
   421  KLGCLLARKG CVEKMQYYWD VGFYLGAQIL ANDPTQVVLA AEQLYKLNAP IWYLVSVMET
   481  FLLYQHFRPT PEPPGGPPRR AHFWLHFLLQ SCQPFKTACA QGDQCLVLVL EMNKVLLPAK
   541  LEVRGTDPVS TVTLSLLEPE TQDIPSSWTF PVASICGVSA SKRDERCCFL YALPPAQDVQ
   601  LCFPSVGHCQ WFCGLIQAWV TNPDSTAPAE EAEGAGEMLE FDYEYTETGE RLVLGKGTYG
   661  VVYAGRDRHT RVRIAIKEIP ERDSRFSQPL HEEIALHRRL RHKNIVRYLG SASQGGYLKI
   721  FMEEVPGGSL SSLLRSVWGP LKDNESTISF YTRQILQGLG YLHDNHIVHR DIKGDNVLIN
   781  TFSGLLKISD FGTSKRLAGI TPCTETFTGT LQYMAPEIID QGPRGYGKAA DIWSLGCTVI
   841  EMATGRPPFH ELGSPQAAMF QVGMYKVHPP MPSSLSAEAQ AFLLRTFEPD PRLRASAQTL
   901  LGDPFLQPGK RSRSPSSPRH APRPSDAPSA SPTPSANSTT QSQTFPCPQA PSQHPPSPPK
   961  RCLSYGGTSQ LRVPEEPAAE EPASPEESSG LSLLHQESKR RAMLAAVLEQ ELPALAENLH
  1021  QEQKQEQGAR LGRNHVEELL RCLGAHIHTP NRRQLAQELR ALQGRLRAQG LGPALLHRPL
  1081  FAFPDAVKQI LRKRQIRPHW MFVLDSLLSR AVRAALGVLG PEVEKEAVSP RSEELSNEGD
  1141  SQQSPGQQSP LPVEPEQGPA PLMVQLSLLR AETDRLREIL AGKEREYQAL VQRALQRLNE
  1201  EARTYVLAPE PPTALSTDQG LVQWLQELNV DSGTIQMLLN HSFTLHTLLT YATRDDLIYT
  1261  RIRGGMVCRI WRAILAQRAG STPVTSGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP3K6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

esophagus: 61 nTPM
skin: 60 nTPM
heart muscle: 58 nTPM
lung: 54 nTPM
vagina: 48 nTPM
cervix: 46 nTPM

Single-cell type

esophageal apical cells: 41 nCPM
vascular endothelial cells: 39 nCPM
esophageal suprabasal cells: 37 nCPM
esophageal basal cells: 31 nCPM
salivary duct cells: 26 nCPM
alveolar cells type 1: 24 nCPM

Immune cell

non-classical monocyte: 4.7 nTPM
MAIT T-cell: 3.8 nTPM
eosinophil: 3.4 nTPM
memory CD8 T-cell: 3.3 nTPM
T-reg: 3.3 nTPM
gdT-cell: 3 nTPM

Brain region

medulla oblongata: 9.3 nTPM
thalamus: 9.3 nTPM
cerebral cortex: 7.7 nTPM
pons: 7.5 nTPM
cerebellum: 7.3 nTPM
midbrain: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 1.24
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAP3K6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MAP3K5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP3K6 as an antibody target. Whether an autoantibody or antibody against MAP3K6 could matter depends on whether native MAP3K6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP3K6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP3K6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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