Seroatlas · Human Serome Atlas

MAP3K19

Mitogen-activated protein kinase kinase kinase 19

Also known as: FLJ23074, M3K19_HUMAN, RCK, YSK4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q56UN5
Gene: MAP3K19
Ensembl: ENSG00000176601
Chromosome: 2
Canonical length: 1328 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in MAPK cascade. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1328 residues, UniProt reviewed canonical sequence.

>Q56UN5|MAP3K19
     1  MSSMPKPERH AESLLDICHD TNSSPTDLMT VTKNQNIILQ SISRSEEFDQ DGDCSHSTLV
    61  NEEEDPSGGR QDWQPRTEGV EITVTFPRDV SPPQEMSQED LKEKNLINSS LQEWAQAHAV
   121  SHPNEIETVE LRKKKLTMRP LVLQKEESSR ELCNVNLGFL LPRSCLELNI SKSVTREDAP
   181  HFLKEQQRKS EEFSTSHMKY SGRSIKFLLP PLSLLPTRSG VLTIPQNHKF PKEKERNIPS
   241  LTSFVPKLSV SVRQSDELSP SNEPPGALVK SLMDPTLRSS DGFIWSRNMC SFPKTNHHRQ
   301  CLEKEENWKS KEIEECNKIE ITHFEKGQSL VSFENLKEGN IPAVREEDID CHGSKTRKPE
   361  EENSQYLSSR KNESSVAKNY EQDPEIVCTI PSKFQETQHS EITPSQDEEM RNNKAASKRV
   421  SLHKNEAMEP NNILEECTVL KSLSSVVFDD PIDKLPEGCS SMETNIKISI AERAKPEMSR
   481  MVPLIHITFP VDGSPKEPVI AKPSLQTRKG TIHNNHSVNI PVHQENDKHK MNSHRSKLDS
   541  KTKTSKKTPQ NFVISTEGPI KPTMHKTSIK TQIFPALGLV DPRPWQLPRF QKKMPQIAKK
   601  QSTHRTQKPK KQSFPCICKN PGTQKSCVPL SVQPTEPRLN YLDLKYSDMF KEINSTANGP
   661  GIYEMFGTPV YCHVRETERD ENTYYREICS APSGRRITNK CRSSHSERKS NIRTRLSQKK
   721  THMKCPKTSF GIKQEHKVLI SKEKSSKAVH SNLHDIENGD GISEPDWQIK SSGNEFLSSK
   781  DEIHPMNLAQ TPEQSMKQNE FPPVSDLSIV EEVSMEESTG DRDISNNQIL TTSLRDLQEL
   841  EELHHQIPFI PSEDSWAVPS EKNSNKYVQQ EKQNTASLSK VNASRILTND LEFDSVSDHS
   901  KTLTNFSFQA KQESASSQTY QYWVHYLDHD SLANKSITYQ MFGKTLSGTN SISQEIMDSV
   961  NNEELTDELL GCLAAELLAL DEKDNNSCQK MANETDPENL NLVLRWRGST PKEMGRETTK
  1021  VKIQRHSSGL RIYDREEKFL ISNEKKIFSE NSLKSEEPIL WTKGEILGKG AYGTVYCGLT
  1081  SQGQLIAVKQ VALDTSNKLA AEKEYRKLQE EVDLLKALKH VNIVAYLGTC LQENTVSIFM
  1141  EFVPGGSISS IINRFGPLPE MVFCKYTKQI LQGVAYLHEN CVVHRDIKGN NVMLMPTGII
  1201  KLIDFGCARR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN ESGYGRKSDI WSIGCTVFEM
  1261  ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENAADF VRMCLTRDQH ERPSALQLLK
  1321  HSFLERSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP3K19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 17 nTPM
choroid plexus: 8.5 nTPM
testis: 3.6 nTPM
hypothalamus: 1.4 nTPM
lung: 1.4 nTPM
basal ganglia: 1.2 nTPM

Single-cell type

ependymal cells: 475 nCPM
respiratory ciliated cells: 380 nCPM
late spermatids: 253 nCPM
fallopian tube ciliated cells: 226 nCPM
endometrial ciliated cells: 191 nCPM
epididymal efferent duct ciliated cells: 156 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 19 nTPM
medulla oblongata: 11 nTPM
spinal cord: 7.7 nTPM
midbrain: 7.4 nTPM
white matter: 5.9 nTPM
hypothalamus: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.76
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

MAPK cascade

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP3K19 as an antibody target. Whether an autoantibody or antibody against MAP3K19 could matter depends on whether native MAP3K19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP3K19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP3K19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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