Seroatlas · Human Serome Atlas

MAP1LC3B2

Microtubule-associated protein 1 light chain 3 beta 2

Also known as: ATG8G, MP3B2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NCE7
Gene: MAP1LC3B2
Ensembl: ENSG00000258102
Chromosome: 12
Canonical length: 125 aa
Protein class: Predicted intracellular proteins
Subcellular location: Primary cilium,Centriolar satellite

OverviewNCBI Gene

Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in cellular response to nitrogen starvation and macroautophagy. Predicted to be located in several cellular components, including cytoplasmic vesicle; endomembrane system; and microtubule. Predicted to be active in autophagosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>A6NCE7|MAP1LC3B2
     1  MPSEKTFKQR RTFEQRVEDV RLIREQHPTK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM
    61  SELIKIIRRR LQLNANQAFF LLVNGHSMVS VSTPISEVYE SEKDEDGFLY MVCASQETFG
   121  MKLSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP1LC3B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 5.8 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 5.8 nTPM
skeletal muscle: 4.1 nTPM
bone marrow: 3.6 nTPM
heart muscle: 2.8 nTPM
adrenal gland: 2.1 nTPM
adipose tissue: 1.8 nTPM

Single-cell type

retinal horizontal cells: 60 nCPM
neutrophils: 42 nCPM
retinal amacrine cells: 22 nCPM
epididymal basal cells: 20 nCPM
brain excitatory neurons: 17 nCPM
bergmann glia: 16 nCPM

Immune cell

neutrophil: 44 nTPM
basophil: 39 nTPM
eosinophil: 34 nTPM
T-reg: 16 nTPM
non-classical monocyte: 14 nTPM
total PBMC: 14 nTPM

Brain region

cerebellum: 6.1 nTPM
hypothalamus: 3.4 nTPM
choroid plexus: 3.3 nTPM
medulla oblongata: 3.2 nTPM
white matter: 3.2 nTPM
cerebral cortex: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0.01
gnomAD missense Z: 0.03
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP1LC3B2 as an antibody target. Whether an autoantibody or antibody against MAP1LC3B2 could matter depends on whether native MAP1LC3B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP1LC3B2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP1LC3B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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