Seroatlas · Human Serome Atlas

MAP10

Microtubule-associated protein 10

Also known as: KIAA1383, MAP10_HUMAN, MTR120

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2G4
Gene: MAP10
Ensembl: ENSG00000212916
Chromosome: 1
Canonical length: 905 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables microtubule binding activity. Involved in microtubule cytoskeleton organization; positive regulation of cytokinesis; and regulation of microtubule-based process. Located in microtubule cytoskeleton and midbody. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

905 residues, UniProt reviewed canonical sequence.

>Q9P2G4|MAP10
     1  MAASLSERLF SLELLVDWVR LEARLLPSPA AAVEQEEEEE EKEQGEASSP RGLCPAVAFR
    61  LLDFPTLLVY PPDGPGAPAA EPWPGVIRFG RGKSCLFRLQ PATLHCRLLR TPLATLLLQL
   121  PPGRPTPTPQ LLGACDISLA TAAHRVVGPA ASGCSHRHRG RFPLHNRVGE RTGDIALAYR
   181  LTDLGSRLLS QLERPLTFTR TGGGAEVSPQ TQQERQQLQQ PASQPSPKEA DKPLGELEIP
   241  EAQKDLKEMV KSKAECDNVG SVENGKTNSV VTCSGAGNGR NVSSLNEEVT ELDMETNIFC
   301  PPPLYYTNLT QEKPPPAQAK ITIEPQMNAP EEMDDASPEK KRVNPPAHRS CLKHPSSAAH
   361  EHPPMLVNPP HIQNIGATNQ TCQTEQNRIN TIRQLPLLNA LLVELSLLYD QPVTSPAHIH
   421  PHLAWLYRTE DKKSPESSAK STCRSEAKKD KRSVGGCEKS VSLQYKKNQI ENYKEDKYSE
   481  KSSGALHKRV PKGRLLYGLT NTLRLRLKLT NPDMLVVHEK RELYRKRQSQ MLGTKFRIPS
   541  SKVKLLSSAE QSQKPQLPED KYLDSDASFT ENSDTSRQIS GVFDEPSTSK ETKLKYATEK
   601  KTVDCSKNRI NNVSLEEVVS PANSIIPERL TPTNILGGNV EMKIQSPCVF QQDAVVDRIV
   661  DKEIDIRQVK TTDNDILMAD ISDKRTGKNS CYENISELKY SDDLSSPCYS EDFCTSEDTS
   721  RSFKAHDSSS RTENPKHSQY TSKSSDTGVS KKKNSSDRSS ILSPPFSAGS PVHSYRKFHI
   781  SKTQDKSLEE ASSISASDLS STHWTEQKEN QIDQNSMHNS EITKRAQDIS VKTRSSWKSL
   841  EKSQSPQTSQ VSSYLPSNVS ELNVLDSSTS DHFEEGNDDV GSLNISKQCK DICELVINKL
   901  PGYTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 2.9 nTPM

Expression across tissuesHPA

Tissue

thymus: 2.9 nTPM
retina: 2.6 nTPM
testis: 2.5 nTPM
epididymis: 2.1 nTPM
liver: 2.1 nTPM
lymph node: 2.1 nTPM

Single-cell type

cardiomyocytes: 16 nCPM
cone photoreceptor cells: 12 nCPM
early primary spermatocytes: 11 nCPM
pancreatic islet cells: 8.2 nCPM
cholangiocytes: 7.9 nCPM
differentiating spermatogonia: 7.8 nCPM

Immune cell

basophil: 3.9 nTPM
non-classical monocyte: 2.5 nTPM
plasmacytoid DC: 2.3 nTPM
myeloid DC: 2 nTPM
classical monocyte: 1.5 nTPM
eosinophil: 1.4 nTPM

Brain region

cerebral cortex: 3 nTPM
basal ganglia: 2.9 nTPM
hypothalamus: 2.9 nTPM
hippocampal formation: 2.7 nTPM
pons: 2.6 nTPM
white matter: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: -1.32
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Microtubule-associated protein 10, C-terminal
Microtubule associated protein 10
Microtubule associated protein 10, N-terminal domain
Domain of unknown function

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAP10 as an antibody target. Whether an autoantibody or antibody against MAP10 could matter depends on whether native MAP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAP10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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