Seroatlas · Human Serome Atlas

MANSC4

MANSC domain-containing protein 4

Also known as: MANS4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NHS7
Gene: MANSC4
Ensembl: ENSG00000205693
Chromosome: 12
Canonical length: 340 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in epidermis development; epithelium development; and extracellular matrix organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>A6NHS7|MANSC4
     1  MHVAEVAVNV ILLLSMGWTS DSLCSPTIFY RDCWIRRFPG LLINLEESQK LGAQFLKYYS
    61  ESTGQKCSRS CCLRKDVSCN LAVFYHSPIH DNINCLHVHC PTLESCILEP GTSAILYNIT
   121  DGIDPDLLVF EQSPTYLNTR SSSNRWDRLR ILKAMNLDKQ TTTINGMLPS TEAPSSTTHQ
   181  DLVVNTNSTS YSKELTTDFW ARFTSLNESI TTKINKVSPS TDFISNPDNK TISPFFEPID
   241  TKLSHMPVPP GLNSSKQLLN KTKGYNSRNH TSANEDEVSV TSKTWLVSVA LCTSVIFLGC
   301  CIVILASGCC GKQQGQYKPG QRKSGSLQIK NRNHMKENSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MANSC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 1.3 nTPM

Expression across tissuesHPA

Tissue

testis: 1.3 nTPM
cerebellum: 0.9 nTPM
pituitary gland: 0.6 nTPM
lymph node: 0.4 nTPM
placenta: 0.4 nTPM
retina: 0.4 nTPM

Single-cell type

sertoli cells: 31 nCPM
podocytes: 10 nCPM
gonadotrophs: 8.1 nCPM
müller glia: 7.5 nCPM
cytotrophoblasts: 6.8 nCPM
myonuclei: 6.6 nCPM

Immune cell

memory CD4 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
naive B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 3.1 nTPM
hypothalamus: 2.4 nTPM
cerebral cortex: 2.2 nTPM
white matter: 2.2 nTPM
amygdala: 2.1 nTPM
hippocampal formation: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: 1.62
DepMap mean gene effect: -0.1
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

serine-type endopeptidase inhibitor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MANSC4 as an antibody target. Whether an autoantibody or antibody against MANSC4 could matter depends on whether native MANSC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MANSC4 is annotated at the cell surface, where native MANSC4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MANSC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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