Seroatlas · Human Serome Atlas

MANSC1

MANSC domain-containing protein 1

Also known as: FLJ10298, LOH12CR3, MANS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8J5
Gene: MANSC1
Ensembl: ENSG00000111261
Chromosome: 12
Canonical length: 431 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>Q9H8J5|MANSC1
     1  MFFGGEGSLT YTLVIICFLT LRLSASQNCL KKSLEDVVID IQSSLSKGIR GNEPVYTSTQ
    61  EDCINSCCST KNISGDKACN LMIFDTRKTA RQPNCYLFFC PNEEACPLKP AKGLMSYRII
   121  TDFPSLTRNL PSQELPQEDS LLHGQFSQAV TPLAHHHTDY SKPTDISWRD TLSQKFGSSD
   181  HLEKLFKMDE ASAQLLAYKE KGHSQSSQFS SDQEIAHLLP ENVSALPATV AVASPHTTSA
   241  TPKPATLLPT NASVTPSGTS QPQLATTAPP VTTVTSQPPT TLISTVFTRA AATLQAMATT
   301  AVLTTTFQAP TDSKGSLETI PFTEISNLTL NTGNVYNPTA LSMSNVESST MNKTASWEGR
   361  EASPGSSSQG SVPENQYGLP FEKWLLIGSL LFGVLFLVIG LVLLGRILSE SLRRKRYSRL
   421  DYLINGIYVD I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MANSC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 66 nTPM
blood vessel: 45 nTPM
esophagus: 39 nTPM
pancreas: 23 nTPM
colon: 21 nTPM
endometrium: 21 nTPM

Single-cell type

ependymal cells: 24 nCPM
brain excitatory neurons: 18 nCPM
renal collecting duct principal cells: 18 nCPM
brain inhibitory neurons: 18 nCPM
papillary tip epithelial cells: 17 nCPM
podocytes: 15 nCPM

Immune cell

neutrophil: 99 nTPM
basophil: 6.5 nTPM
naive CD4 T-cell: 2.5 nTPM
classical monocyte: 1.2 nTPM
eosinophil: 1 nTPM
intermediate monocyte: 0.9 nTPM

Brain region

cerebral cortex: 13 nTPM
choroid plexus: 12 nTPM
basal ganglia: 9.7 nTPM
hippocampal formation: 9.5 nTPM
white matter: 9.3 nTPM
cerebellum: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0.01
gnomAD missense Z: 0.28
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MANSC1 as an antibody target. Whether an autoantibody or antibody against MANSC1 could matter depends on whether native MANSC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MANSC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MANSC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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