Seroatlas · Human Serome Atlas

MANBAL

Protein MANBAL

Also known as: dJ1141E15.2, MANBL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NQG1
Gene
MANBAL
Ensembl
ENSG00000101363
Chromosome
20
Canonical length
85 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

85 residues, UniProt reviewed canonical sequence.

>Q9NQG1|MANBAL
     1  MASDLDFSPP EVPEPTFLEN LLRYGLFLGA IFQLICVLAI IVPIPKSHEA EAEPSEPRSA
    61  EVTRKPKAAV PSVNKRPKKE TKKKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MANBAL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
93 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 93 nTPM
  • colon: 91 nTPM
  • choroid plexus: 86 nTPM
  • endometrium: 85 nTPM
  • urinary bladder: 83 nTPM
  • prostate: 76 nTPM

Single-cell type

  • extravillous trophoblasts: 174 nCPM
  • esophageal apical cells: 138 nCPM
  • decidual stromal cells: 122 nCPM
  • smooth muscle cells: 115 nCPM
  • cytotrophoblasts: 115 nCPM
  • migrating cytotrophoblasts: 109 nCPM

Immune cell

  • neutrophil: 35 nTPM
  • eosinophil: 35 nTPM
  • plasmacytoid DC: 30 nTPM
  • intermediate monocyte: 28 nTPM
  • naive B-cell: 27 nTPM
  • memory B-cell: 25 nTPM

Brain region

  • thalamus: 54 nTPM
  • hypothalamus: 51 nTPM
  • pons: 49 nTPM
  • hippocampal formation: 48 nTPM
  • medulla oblongata: 47 nTPM
  • midbrain: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0.03
gnomAD missense Z
0.16
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Uncharacterised protein family UPF0239
  • Uncharacterised protein family (UPF0239)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MANBAL as an antibody target. Whether an autoantibody or antibody against MANBAL could matter depends on whether native MANBAL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MANBAL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MANBAL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MANBAL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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