Seroatlas · Human Serome Atlas

MAN1C1

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

Also known as: HMIC, MA1C1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NR34
Gene
MAN1C1
Ensembl
ENSG00000117643
Chromosome
1
Canonical length
630 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in ERAD pathway. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

630 residues, UniProt reviewed canonical sequence.

>Q9NR34|MAN1C1
     1  MLMRKVPGFV PASPWGLRLP QKFLFLLFLS GLVTLCFGAL FLLPHSSRLK RLFLAPRTQQ
    61  PGLEVVAEIA GHAPAREQEP PPNPAPAAPA PGEDDPSSWA SPRRRKGGLR RTRPTGPREE
   121  ATAARGNSIP ASRPGDEGVP FRFDFNAFRS RLRHPVLGTR ADESQEPQSQ VRAQREKIKE
   181  MMQFAWQSYK RYAMGKNELR PLTKDGYEGN MFGGLSGATV IDSLDTLYLM ELKEEFQEAK
   241  AWVGESFHLN VSGEASLFEV NIRYIGGLLS AFYLTGEEVF RIKAIRLGEK LLPAFNTPTG
   301  IPKGVVSFKS GNWGWATAGS SSILAEFGSL HLEFLHLTEL SGNQVFAEKV RNIRKVLRKI
   361  EKPFGLYPNF LSPVSGNWVQ HHVSVGGLGD SFYEYLIKSW LMSGKTDMEA KNMYYEALEA
   421  IETYLLNVSP GGLTYIAEWR GGILDHKMGH LACFSGGMIA LGAEDAKEEK RAHYRELAAQ
   481  ITKTCHESYA RSDTKLGPEA FWFNSGREAV ATQLSESYYI LRPEVVESYM YLWRQTHNPI
   541  YREWGWEVVL ALEKYCRTEA GFSGIQDVYS STPNHDNKQQ SFFLAETLKY LYLLFSEDDL
   601  LSLEDWVFNT EAHPLPVNHS DSSGRAWGRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAN1C1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 30 nTPM
  • liver: 28 nTPM
  • thyroid gland: 24 nTPM
  • kidney: 24 nTPM
  • parathyroid gland: 23 nTPM
  • cerebellum: 20 nTPM

Single-cell type

  • cone photoreceptor cells: 356 nCPM
  • choroid plexus epithelial cells: 285 nCPM
  • syncytiotrophoblasts: 284 nCPM
  • thyrotrophs: 253 nCPM
  • renal collecting duct intercalated cells: 251 nCPM
  • somatotrophs: 201 nCPM

Immune cell

  • naive CD4 T-cell: 4.8 nTPM
  • naive CD8 T-cell: 2.8 nTPM
  • memory CD4 T-cell: 2.1 nTPM
  • classical monocyte: 1 nTPM
  • memory CD8 T-cell: 0.9 nTPM
  • non-classical monocyte: 0.8 nTPM

Brain region

  • medulla oblongata: 103 nTPM
  • white matter: 85 nTPM
  • spinal cord: 70 nTPM
  • choroid plexus: 65 nTPM
  • midbrain: 56 nTPM
  • pons: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.21
gnomAD missense Z
1.66
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAN1C1 as an antibody target. Whether an autoantibody or antibody against MAN1C1 could matter depends on whether native MAN1C1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAN1C1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAN1C1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAN1C1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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