Seroatlas · Human Serome Atlas

MAN1A2

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

Also known as: MA1A2_HUMAN, MAN1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60476
Gene
MAN1A2
Ensembl
ENSG00000198162
Chromosome
1
Canonical length
641 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

641 residues, UniProt reviewed canonical sequence.

>O60476|MAN1A2
     1  MTTPALLPLS GRRIPPLNLG PPSFPHHRAT LRLSEKFILL LILSAFITLC FGAFFFLPDS
    61  SKHKRFDLGL EDVLIPHVDA GKGAKNPGVF LIHGPDEHRH REEEERLRNK IRADHEKALE
   121  EAKEKLRKSR EEIRAEIQTE KNKVVQEMKI KENKPLPPVP IPNLVGIRGG DPEDNDIREK
   181  REKIKEMMKH AWDNYRTYGW GHNELRPIAR KGHSPNIFGS SQMGATIVDA LDTLYIMGLH
   241  DEFLDGQRWI EDNLDFSVNS EVSVFEVNIR FIGGLLAAYY LSGEEIFKIK AVQLAEKLLP
   301  AFNTPTGIPW AMVNLKSGVG RNWGWASAGS SILAEFGTLH MEFIHLSYLT GDLTYYKKVM
   361  HIRKLLQKMD RPNGLYPNYL NPRTGRWGQY HTSVGGLGDS FYEYLLKAWL MSDKTDHEAR
   421  KMYDDAIEAI EKHLIKKSRG GLTFIGEWKN GHLEKKMGHL ACFAGGMFAL GADGSRADKA
   481  GHYLELGAEI ARTCHESYDR TALKLGPESF KFDGAVEAVA VRQAEKYYIL RPEVIETYWY
   541  LWRFTHDPRY RQWGWEAALA IEKYCRVNGG FSGVKDVYSS TPTHDDVQQS FFLAETLKYL
   601  YLLFSGDDLL PLDHWVFNTE AHPLPVLHLA NTTLSGNPAV R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAN1A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 34 nTPM
  • parathyroid gland: 31 nTPM
  • thyroid gland: 24 nTPM
  • placenta: 20 nTPM
  • liver: 20 nTPM
  • retina: 17 nTPM

Single-cell type

  • syncytiotrophoblasts: 913 nCPM
  • extravillous trophoblasts: 676 nCPM
  • choroid plexus epithelial cells: 368 nCPM
  • plasma cells: 322 nCPM
  • pancreatic acinar cells: 317 nCPM
  • corticotrophs: 286 nCPM

Immune cell

  • T-reg: 6.3 nTPM
  • NK-cell: 3.9 nTPM
  • MAIT T-cell: 3.6 nTPM
  • gdT-cell: 3 nTPM
  • naive CD8 T-cell: 2.9 nTPM
  • plasmacytoid DC: 2.7 nTPM

Brain region

  • basal ganglia: 58 nTPM
  • cerebral cortex: 56 nTPM
  • white matter: 52 nTPM
  • cerebellum: 51 nTPM
  • hypothalamus: 51 nTPM
  • choroid plexus: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
1
gnomAD missense Z
2.56
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAN1A2 as an antibody target. Whether an autoantibody or antibody against MAN1A2 could matter depends on whether native MAN1A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAN1A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAN1A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAN1A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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