Seroatlas · Human Serome Atlas

MAN1A1

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

Also known as: MA1A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P33908
Gene
MAN1A1
Ensembl
ENSG00000111885
Chromosome
6
Canonical length
653 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus

OverviewNCBI Gene

This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

653 residues, UniProt reviewed canonical sequence.

>P33908|MAN1A1
     1  MPVGGLLPLF SSPAGGVLGG GLGGGGGRKG SGPAALRLTE KFVLLLVFSA FITLCFGAIF
    61  FLPDSSKLLS GVLFHSSPAL QPAADHKPGP GARAEDAAEG RARRREEGAP GDPEAALEDN
   121  LARIRENHER ALREAKETLQ KLPEEIQRDI LLEKKKVAQD QLRDKAPFRG LPPVDFVPPI
   181  GVESREPADA AIREKRAKIK EMMKHAWNNY KGYAWGLNEL KPISKGGHSS SLFGNIKGAT
   241  IVDALDTLFI MEMKHEFEEA KSWVEENLDF NVNAEISVFE VNIRFVGGLL SAYYLSGEEI
   301  FRKKAVELGV KLLPAFHTPS GIPWALLNMK SGIGRNWPWA SGGSSILAEF GTLHLEFMHL
   361  SHLSGNPIFA EKVMNIRTVL NKLEKPQGLY PNYLNPSSGQ WGQHHVSVGG LGDSFYEYLL
   421  KAWLMSDKTD LEAKKMYFDA VQAIETHLIR KSSSGLTYIA EWKGGLLEHK MGHLTCFAGG
   481  MFALGADAAP EGMAQHYLEL GAEIARTCHE SYNRTFMKLG PEAFRFDGGV EAIATRQNEK
   541  YYILRPEVME TYMYMWRLTH DPKYRKWAWE AVEALENHCR VNGGYSGLRD VYLLHESYDD
   601  VQQSFFLAET LKYLYLIFSD DDLLPLEHWI FNSEAHLLPI LPKDKKEVEI REE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAN1A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
145 nTPM

Expression across tissuesHPA

Tissue

  • liver: 145 nTPM
  • adipose tissue: 96 nTPM
  • placenta: 75 nTPM
  • small intestine: 66 nTPM
  • kidney: 62 nTPM
  • urinary bladder: 53 nTPM

Single-cell type

  • macrophages: 846 nCPM
  • hematopoietic stem cells: 809 nCPM
  • plasma cells: 755 nCPM
  • thymocytes: 638 nCPM
  • neutrophils: 567 nCPM
  • lymphatic endothelial cells: 557 nCPM

Immune cell

  • basophil: 4.3 nTPM
  • plasmacytoid DC: 2.9 nTPM
  • MAIT T-cell: 2.3 nTPM
  • neutrophil: 1.9 nTPM
  • eosinophil: 1.1 nTPM
  • gdT-cell: 1.1 nTPM

Brain region

  • basal ganglia: 29 nTPM
  • cerebral cortex: 22 nTPM
  • hypothalamus: 22 nTPM
  • hippocampal formation: 20 nTPM
  • white matter: 16 nTPM
  • midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0.11
gnomAD missense Z
1.51
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAN1A1 as an antibody target. Whether an autoantibody or antibody against MAN1A1 could matter depends on whether native MAN1A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAN1A1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAN1A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAN1A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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