Seroatlas · Human Serome Atlas

MAMSTR

MEF2-activating motif and SAP domain-containing transcriptional regulator

Also known as: FLJ36070, MASTR, MASTR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZN01
Gene
MAMSTR
Ensembl
ENSG00000176909
Chromosome
19
Canonical length
415 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of myotube differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

415 residues, UniProt reviewed canonical sequence.

>Q6ZN01|MAMSTR
     1  MTLAASSQRS QIIRSKFRSV LQLRIHRRNQ EQISDPDPWI SASDPPLAPA LPSGTAPFLF
    61  SPGVLLPEPE YCPPWRSPKK ESPKISQRWR ESKPRGNLTY HQYMPPEPRQ GSRADPQAEG
   121  SALGPPGPSL WEGTDSQQPH PRMKPSPLTP CPPGVPSPSP PPHKLELQTL KLEELTVSEL
   181  RQQLRLRGLP VSGTKSMLLE RMRGGAPPRE RPKPRREDSP AGAPWPRLKP KALAAARRQG
   241  SVKPSAASHR PPLPRAADTP GTAPAPTPTP APAAAPALTP SSGPGSAALT LEEELQEAIR
   301  RAQLLPNRGI DDILEDQVEP DDPLPPIPLD FPGSFDVLSP SPDSEGLSSV FSSSLPSPTN
   361  SSSPSPRDPT DSLDWLEALS GGPPLGSGPP PPSIFSADLS DSSSSRLWDL LEDPW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAMSTR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
83 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 83 nTPM
  • adrenal gland: 31 nTPM
  • tongue: 21 nTPM
  • endometrium: 11 nTPM
  • fallopian tube: 9.4 nTPM
  • testis: 8.9 nTPM

Single-cell type

  • myonuclei: 271 nCPM
  • adrenal cortex cells: 109 nCPM
  • granulosa cells: 58 nCPM
  • sertoli cells: 21 nCPM
  • gonadotrophs: 16 nCPM
  • mesothelial cells: 16 nCPM

Immune cell

  • naive B-cell: 2.1 nTPM
  • memory CD4 T-cell: 1.7 nTPM
  • naive CD4 T-cell: 1.7 nTPM
  • gdT-cell: 1.6 nTPM
  • memory CD8 T-cell: 1.6 nTPM
  • naive CD8 T-cell: 1.5 nTPM

Brain region

  • cerebellum: 22 nTPM
  • cerebral cortex: 11 nTPM
  • amygdala: 9 nTPM
  • hippocampal formation: 8.8 nTPM
  • basal ganglia: 8.7 nTPM
  • white matter: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0.01
gnomAD missense Z
0.57
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAMSTR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAMSTR as an antibody target. Whether an autoantibody or antibody against MAMSTR could matter depends on whether native MAMSTR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAMSTR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAMSTR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAMSTR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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