MAML3

Protein identityUniProt · HPA

UniProt accession

Q96JK9

Gene

MAML3

Ensembl

ENSG00000196782

Chromosome

4

Canonical length

1138 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nuclear speckles

OverviewNCBI Gene

Enables transcription coactivator activity. Involved in Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1138 residues, UniProt reviewed canonical sequence.

>Q96JK9|MAML3
     1  MGDFAAPAAA ANGSSICINS SLNSSLGGAG IGVNNTPNST PAAPSSNHPA AGGCGGSGGP
    61  GGGSAAVPKH STVVERLRQR IEGCRRHHVN CENRYQQAQV EQLELERRDT VSLYQRTLEQ
   121  RAKKSGAGTG KQQHPSKPQQ DAEAASAEQR NHTLIMLQET VKRKLEGARS PLNGDQQNGA
   181  CDGNFSPTSK RIRKDISAGM EAINNLPSNM PLPSASPLHQ LDLKPSLPLQ NSGTHTPGLL
   241  EDLSKNGRLP EIKLPVNGCS DLEDSFTILQ SKDLKQEPLD DPTCIDTSET SLSNQNKLFS
   301  DINLNDQEWQ ELIDELANTV PEDDIQDLFN EDFEEKKEPE FSQPATETPL SQESASVKSD
   361  PSHSPFAHVS MGSPQARPSS SGPPFSTVST ATSLPSVAST PAAPNPASSP ANCAVQSPQT
   421  PNQAHTPGQA PPRPGNGYLL NPAAVTVAGS ASGPVAVPSS DMSPAEQLKQ MAAQQQQRAK
   481  LMQQKQQQQQ QQQQQQQQQQ QQQQQQQQQQ HSNQTSNWSP LGPPSSPYGA AFTAEKPNSP
   541  MMYPQAFNNQ NPIVPPMANN LQKTTMNNYL PQNHMNMINQ QPNNLGTNSL NKQHNILTYG
   601  NTKPLTHFNA DLSQRMTPPV ANPNKNPLMP YIQQQQQQQQ QQQQQQQQQQ PPPPQLQAPR
   661  AHLSEDQKRL LLMKQKGVMN QPMAYAALPS HGQEQHPVGL PRTTGPMQSS VPPGSGGMVS
   721  GASPAGPGFL GSQPQAAIMK QMLIDQRAQL IEQQKQQFLR EQRQQQQQQQ QQILAEQQLQ
   781  QSHLPRQHLQ PQRNPYPVQQ VNQFQGSPQD IAAVRSQAAL QSMRTSRLMA QNAGMMGIGP
   841  SQNPGTMATA AAQSEMGLAP YSTTPTSQPG MYNMSTGMTQ MLQHPNQSGM SITHNQAQGP
   901  RQPASGQGVG MVSGFGQSML VNSAITQQHP QMKGPVGQAL PRPQAPPRLQ SLMGTVQQGA
   961  QSWQQRSLQG MPGRTSGELG PFNNGASYPL QAGQPRLTKQ HFPQGLSQSV VDANTGTVRT
  1021  LNPAAMGRQM MPSLPGQQGT SQARPMVMSG LSQGVPGMPA FSQPPAQQQI PSGSFAPSSQ
  1081  SQAYERNAPQ DVSYNYSGDG AGGSFPGLPD GADLVDSIIK GGPGDEWMQE LDELFGNP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAML3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

7.6 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.22

gnomAD pLI

1

gnomAD missense Z

0.9

DepMap mean gene effect

0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• Notch signaling pathway
• positive regulation of transcription by RNA polymerase II
• positive regulation of transcription of Notch receptor target

Molecular functions

• transcription coactivator activity

Cellular components

• nuclear speck
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Neurogenic mastermind-like, N-terminal
• Mastermind-like 1-3
• Neurogenic mastermind-like, N-terminal domain superfamily
• Mastermind-like 1/3, transactivation domain 2
• MamL-1 domain
• Mastermind-like 1/3, transactivation domain 2

KeywordsUniProt

• Acetylation
• Activator
• Notch signaling pathway
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of MAML3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NOTCH1