Seroatlas · Human Serome Atlas

MAMDC4

Apical endosomal glycoprotein

Also known as: AEGP, AEGP_HUMAN, DKFZp434M1411, EDTB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXC1
Gene: MAMDC4
Ensembl: ENSG00000177943
Chromosome: 9
Canonical length: 1216 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable protein histidine phosphatase activity. Predicted to be involved in peptidyl-histidine dephosphorylation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1216 residues, UniProt reviewed canonical sequence.

>Q6UXC1|MAMDC4
     1  MPLSSHLLPA LVLFLAGSSG WAWVPNHCRS PGQAVCNFVC DCRDCSDEAQ CGYHGASPTL
    61  GAPFACDFEQ DPCGWRDIST SGYSWLRDRA GAALEGPGPH SDHTLGTDLG WYMAVGTHRG
   121  KEASTAALRS PTLREAASSC KLRLWYHAAS GDVAELRVEL THGAETLTLW QSTGPWGPGW
   181  QELAVTTGRI RGDFRVTFSA TRNATHRGAV ALDDLEFWDC GLPTPQANCP PGHHHCQNKV
   241  CVEPQQLCDG EDNCGDLSDE NPLTCGRHIA TDFETGLGPW NRSEGWSRNH RAGGPERPSW
   301  PRRDHSRNSA QGSFLVSVAE PGTPAILSSP EFQASGTSNC SLVFYQYLSG SEAGCLQLFL
   361  QTLGPGAPRA PVLLRRRRGE LGTAWVRDRV DIQSAYPFQI LLAGQTGPGG VVGLDDLILS
   421  DHCRPVSEVS TLQPLPPGPR APAPQPLPPS SRLQDSCKQG HLACGDLCVP PEQLCDFEEQ
   481  CAGGEDEQAC GTTDFESPEA GGWEDASVGR LQWRRVSAQE SQGSSAAAAG HFLSLQRAWG
   541  QLGAEARVLT PLLGPSGPSC ELHLAYYLQS QPRGFLALVV VDNGSRELAW QALSSSAGIW
   601  KVDKVLLGAR RRPFRLEFVG LVDLDGPDQQ GAGVDNVTLR DCSPTVTTER DREVSCNFER
   661  DTCSWYPGHL SDTHWRWVES RGPDHDHTTG QGHFVLLDPT DPLAWGHSAH LLSRPQVPAA
   721  PTECLSFWYH LHGPQIGTLR LAMRREGEET HLWSRSGTQG NRWHEAWATL SHQPGSHAQY
   781  QLLFEGLRDG YHGTMALDDV AVRPGPCWAP NYCSFEDSDC GFSPGGQGLW RRQANASGHA
   841  AWGPPTDHTT ETAQGHYMVV DTSPDALPRG QTASLTSKEH RPLAQPACLT FWYHGSLRSP
   901  GTLRVYLEER GRHQVLSLSA HGGLAWRLGS MDVQAERAWR VVFEAVAAGV AHSYVALDDL
   961  LLQDGPCPQP GSCDFESGLC GWSHLAWPGL GGYSWDWGGG ATPSRYPQPP VDHTLGTEAG
  1021  HFAFFETGVL GPGGRAAWLR SEPLPATPAS CLRFWYHMGF PEHFYKGELK VLLHSAQGQL
  1081  AVWGAGGHRR HQWLEAQVEV ASAKEFQIVF EATLGGQPAL GPIALDDVEY LAGQHCQQPA
  1141  PSPGNTAAPG SVPAVVGSAL LLLMLLVLLG LGGRRWLQKK GSCPFQSNTE ATAPGFDNIL
  1201  FNADGVTLPA SVTSDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAMDC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

liver: 31 nTPM
cerebellum: 29 nTPM
pituitary gland: 15 nTPM
thyroid gland: 11 nTPM
kidney: 9.6 nTPM
spleen: 9.2 nTPM

Single-cell type

hepatocytes: 30 nCPM
goblet cells: 25 nCPM
colonocytes: 25 nCPM
tuft cells: 23 nCPM
enterocytes: 21 nCPM
retinal horizontal cells: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 17 nTPM
white matter: 8.5 nTPM
cerebral cortex: 7.1 nTPM
pons: 6.8 nTPM
medulla oblongata: 6.4 nTPM
midbrain: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: -0.84
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAMDC4 as an antibody target. Whether an autoantibody or antibody against MAMDC4 could matter depends on whether native MAMDC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAMDC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAMDC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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