Seroatlas · Human Serome Atlas

MAMDC2

MAM domain-containing protein 2

Also known as: MAMC2_HUMAN, MGC21981

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z304
Gene: MAMDC2
Ensembl: ENSG00000165072
Chromosome: 9
Canonical length: 686 aa
Protein class: Predicted secreted proteins
Subcellular location: Nuclear speckles,Plasma membrane
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable glycosaminoglycan binding activity. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

686 residues, UniProt reviewed canonical sequence.

>Q7Z304|MAMDC2
     1  MLLRGVLLAL QALQLAGALD LPAGSCAFEE STCGFDSVLA SLPWILNEEG HYIYVDTSFG
    61  KQGEKAVLLS PDLQAEEWSC LRLVYQITTS SESLSDPSQL NLYMRFEDES FDRLLWSAKE
   121  PSDSWLIASL DLQNSSKKFK ILIEGVLGQG NTASIALFEI KMTTGYCIEC DFEENHLCGF
   181  VNRWNPNVNW FVGGGSIRNV HSILPQDHTF KSELGHYMYV DSVYVKHFQE VAQLISPLTT
   241  APMAGCLSFY YQIQQGNDNV FSLYTRDVAG LYEEIWKADR PGNAAWNLAE VEFSAPYPME
   301  VIFEVAFNGP KGGYVALDDI SFSPVHCQNQ TELLFSAVEA SCNFEQDLCN FYQDKEGPGW
   361  TRVKVKPNMY RAGDHTTGLG YYLLANTKFT SQPGYIGRLY GPSLPGNLQY CLRFHYAIYG
   421  FLKMSDTLAV YIFEENHVVQ EKIWSVLESP RGVWMQAEIT FKKPMPTKVV FMSLCKSFWD
   481  CGLVALDDIT IQLGSCSSSE KLPPPPGECT FEQDECTFTQ EKRNRSSWHR RRGETPTSYT
   541  GPKGDHTTGV GYYMYIEASH MVYGQKARLL SRPLRGVSGK HCLTFFYHMY GGGTGLLSVY
   601  LKKEEDSEES LLWRRRGEQS ISWLRALIEY SCERQHQIIF EAIRGVSIRS DIAIDDVKFQ
   661  AGPCGEMEDT TQQSSGYSED LNEIEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAMDC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

endometrium: 72 nTPM
fallopian tube: 61 nTPM
ovary: 49 nTPM
colon: 46 nTPM
lung: 38 nTPM
cervix: 36 nTPM

Single-cell type

leydig cells: 154 nCPM
smooth muscle cells: 142 nCPM
fibroblasts: 132 nCPM
peritubular myoid cells: 130 nCPM
macrophages: 117 nCPM
epicardial cells: 116 nCPM

Immune cell

NK-cell: 0.6 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 6 nTPM
thalamus: 4.8 nTPM
cerebral cortex: 4.3 nTPM
hypothalamus: 4.2 nTPM
midbrain: 3.6 nTPM
white matter: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAMDC2 as an antibody target. Whether an autoantibody or antibody against MAMDC2 could matter depends on whether native MAMDC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAMDC2 is annotated as secreted, so native MAMDC2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MAMDC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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