MALL
MAL-like protein
Also known as: BENE, MALL_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q13021
- Gene
- MALL
- Ensembl
- ENSG00000144063
- Chromosome
- 2
- Canonical length
- 153 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
OverviewNCBI Gene
This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts. It interacts with caveolin-1. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
153 residues, UniProt reviewed canonical sequence.
>Q13021|MALL
1 MASPDPPATS YAPSDVPSGV ALFLTIPFAF FLPELIFGFL VWTMVAATHI VYPLLQGWVM
61 YVSLTSFLIS LMFLLSYLFG FYKRFESWRV LDSLYHGTTG ILYMSAAVLQ VHATIVSEKL
121 LDPRIYYINS AASFFAFIAT LLYILHAFSI YYHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MALL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 483 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 483 nTPM
- duodenum: 222 nTPM
- small intestine: 206 nTPM
- vagina: 190 nTPM
- cervix: 135 nTPM
- colon: 107 nTPM
Single-cell type
- esophageal apical cells: 71 nCPM
- enterocytes: 54 nCPM
- urothelial cells: 50 nCPM
- ocular epithelial cells: 45 nCPM
- esophageal suprabasal cells: 23 nCPM
- prostatic club cells: 23 nCPM
Immune cell
- basophil: 8.2 nTPM
- neutrophil: 2.4 nTPM
- NK-cell: 1.2 nTPM
- eosinophil: 0.6 nTPM
- memory B-cell: 0.6 nTPM
- naive B-cell: 0.6 nTPM
Brain region
- hypothalamus: 12 nTPM
- thalamus: 9.6 nTPM
- spinal cord: 7.6 nTPM
- choroid plexus: 7.2 nTPM
- pons: 7.1 nTPM
- midbrain: 6.5 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about MALL.
Disease | ImmuneIEDB
Conditions an epitope on MALL was assayed in.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.41
- gnomAD pLI
- 0.23
- gnomAD missense Z
- 1.06
- DepMap mean gene effect
- -0.26
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MALL as an antibody target. Whether an autoantibody or antibody against MALL could matter depends on whether native MALL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MALL is annotated at the cell surface, where native MALL is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label MALL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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