Seroatlas · Human Serome Atlas

MAJIN

Membrane-anchored junction protein

Also known as: C11orf85, MAJIN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3KP22
Gene: MAJIN
Ensembl: ENSG00000168070
Chromosome: 11
Canonical length: 176 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA binding activity. Predicted to be involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Predicted to act upstream of or within double-strand break repair involved in meiotic recombination; oogenesis; and spermatogenesis. Predicted to be located in chromosome, telomeric region. Predicted to be active in nuclear inner membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>Q3KP22|MAJIN
     1  MSLKPFTYPF PETRFLHAGP NVYKFKIRYG KSIRGEEIEN KEVITQELEV PVEKKAVGAV
    61  MRKRKHMDEP SSPSRPGLDR AKIGTSSQGP SKKKPPVETR RNRERKTQQG LQETLASDIT
   121  DVQKQDSEWG HSLPGRIVPP LQHNSPPPKE RAATGFFGFL SSLFPFRYFF RKSSHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAJIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
gallbladder: 2.7 nTPM
epididymis: 1.9 nTPM
kidney: 1.3 nTPM
lymph node: 1.3 nTPM
tonsil: 1.3 nTPM

Single-cell type

early primary spermatocytes: 253 nCPM
differentiating spermatogonia: 32 nCPM
late primary spermatocytes: 27 nCPM
epididymal efferent duct ciliated cells: 23 nCPM
epididymal basal cells: 15 nCPM
proximal tubule cells: 12 nCPM

Immune cell

memory B-cell: 1.3 nTPM
naive B-cell: 0.6 nTPM
memory CD4 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 6.1 nTPM
basal ganglia: 2.1 nTPM
cerebral cortex: 2.1 nTPM
medulla oblongata: 2 nTPM
white matter: 1.8 nTPM
pons: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Membrane-anchored junction protein
Membrane-anchored junction protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAJIN as an antibody target. Whether an autoantibody or antibody against MAJIN could matter depends on whether native MAJIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAJIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAJIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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