Seroatlas · Human Serome Atlas

MAIP1

m-AAA protease-interacting protein 1, mitochondrial

Also known as: C2orf47, DKFZp666A212, FLJ22555, MAIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWC4
Gene: MAIP1
Ensembl: ENSG00000162972
Chromosome: 2
Canonical length: 291 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable ribosome binding activity. Involved in calcium import into the mitochondrion; mitochondrial calcium ion homeostasis; and protein insertion into mitochondrial membrane. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>Q8WWC4|MAIP1
     1  MALAARLLPQ FLHSRSLPCG AVRLRTPAVA EVRLPSATLC YFCRCRLGLG AALFPRSARA
    61  LAASALPAQG SRWPVLSSPG LPAAFASFPA CPQRSYSTEE KPQQHQKTKM IVLGFSNPIN
   121  WVRTRIKAFL IWAYFDKEFS ITEFSEGAKQ AFAHVSKLLS QCKFDLLEEL VAKEVLHALK
   181  EKVTSLPDNH KNALAANIDE IVFTSTGDIS IYYDEKGRKF VNILMCFWYL TSANIPSETL
   241  RGASVFQVKL GNQNVETKQL LSASYEFQRE FTQGVKPDWT IARIEHSKLL E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

liver: 43 nTPM
kidney: 29 nTPM
skeletal muscle: 21 nTPM
duodenum: 20 nTPM
bone marrow: 18 nTPM
small intestine: 16 nTPM

Single-cell type

oocytes: 101 nCPM
hepatocytes: 54 nCPM
parietal cells: 53 nCPM
extravillous trophoblasts: 45 nCPM
enterocytes: 43 nCPM
esophageal apical cells: 42 nCPM

Immune cell

myeloid DC: 17 nTPM
naive B-cell: 14 nTPM
T-reg: 14 nTPM
memory B-cell: 14 nTPM
plasmacytoid DC: 14 nTPM
MAIT T-cell: 13 nTPM

Brain region

cerebellum: 21 nTPM
cerebral cortex: 17 nTPM
white matter: 17 nTPM
pons: 15 nTPM
basal ganglia: 15 nTPM
hippocampal formation: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ribosome binding

Cellular components

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAIP1 as an antibody target. Whether an autoantibody or antibody against MAIP1 could matter depends on whether native MAIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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