Seroatlas · Human Serome Atlas

MAGIX

PDZ domain-containing protein MAGIX

Also known as: FLJ21687, JM10, MAGIX_HUMAN, PDZX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H6Y5
Gene: MAGIX
Ensembl: ENSG00000269313
Chromosome: X
Canonical length: 334 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitotic chromosome

OverviewNCBI Gene

No narrative summary is available for MAGIX in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>Q9H6Y5|MAGIX
     1  MEPRTGDAAD PRGSRGGRGP SPLAGPSARQ LLARLDARPL AARAAVDVAA LVRRAGATLR
    61  LRRKEAVSVL DSADIEVTDS RLPHATIVDH RPQHRWLETC NAPPQLIQGK ARSAPKPSQA
   121  SGHFSVELVR GYAGFGLTLG GGRDVAGDTP LAVRGLLKDG PAQRCGRLEV GDLVLHINGE
   181  STQGLTHAQA VERIRAGGPQ LHLVIRRPLE THPGKPRGVG EPRKGVVPSW PDRSPDPGGP
   241  EVTGSRSSST SLVQHPPSRT TLKKTRGSPE PSPEAAADGP TVSPPERRAE DPNDQIPGSP
   301  GPWLVPSEER LSRALGVRGA AQLAQEMAAG RRRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGIX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

liver: 19 nTPM
cerebellum: 14 nTPM
pancreas: 13 nTPM
stomach: 12 nTPM
kidney: 11 nTPM
choroid plexus: 9.5 nTPM

Single-cell type

breast lactating cells: 129 nCPM
fallopian tube ciliated cells: 66 nCPM
tuft cells: 58 nCPM
respiratory ciliated cells: 50 nCPM
megakaryocytes: 43 nCPM
epididymal efferent duct ciliated cells: 42 nCPM

Immune cell

neutrophil: 4.2 nTPM
basophil: 3.1 nTPM
eosinophil: 1.8 nTPM
plasmacytoid DC: 1.3 nTPM
classical monocyte: 1 nTPM
non-classical monocyte: 1 nTPM

Brain region

cerebellum: 18 nTPM
choroid plexus: 14 nTPM
pons: 7.4 nTPM
midbrain: 7.1 nTPM
medulla oblongata: 6.8 nTPM
hippocampal formation: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

PDZ domain
PDZ superfamily
PDZ domain
PDZ domain-containing protein MAGIX

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGIX as an antibody target. Whether an autoantibody or antibody against MAGIX could matter depends on whether native MAGIX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGIX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGIX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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