Seroatlas · Human Serome Atlas

MACROD2

ADP-ribose glycohydrolase MACROD2

Also known as: C20orf133, dJ631M13.5, MACD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A1Z1Q3
Gene
MACROD2
Ensembl
ENSG00000172264
Chromosome
20
Canonical length
425 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene is a deacetylase involved in removing ADP-ribose from mono-ADP-ribosylated proteins. The encoded protein has been shown to translocate from the nucleus to the cytoplasm upon DNA damage. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>A1Z1Q3|MACROD2
     1  MYPSNKKKKV WREEKERLLK MTLEERRKEY LRDYIPLNSI LSWKEEMKGK GQNDEENTQE
    61  TSQVKKSLTE KVSLYRGDIT LLEVDAIVNA ANASLLGGGG VDGCIHRAAG PCLLAECRNL
   121  NGCDTGHAKI TCGYDLPAKY VIHTVGPIAR GHINGSHKED LANCYKSSLK LVKENNIRSV
   181  AFPCISTGIY GFPNEPAAVI ALNTIKEWLA KNHHEVDRII FCVFLEVDFK IYKKKMNEFF
   241  SVDDNNEEEE DVEMKEDSDE NGPEEKQSVE EMEEQSQDAD GVNTVTVPGP ASEEAVEDCK
   301  DEDFAKDENI TKGGEVTDHS VRDQDHPDGQ ENDSTKNEIK IETESQSSYM ETEELSSNQE
   361  DAVIVEQPEV IPLTEDQEEK EGEKAPGEDT PRMPGKSEGS SDLENTPGPD AGAQDEAKEQ
   421  RNGTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MACROD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • lung: 10 nTPM
  • basal ganglia: 9.8 nTPM
  • seminal vesicle: 9.1 nTPM
  • cerebral cortex: 8 nTPM
  • fallopian tube: 6.6 nTPM
  • tonsil: 4.8 nTPM

Single-cell type

  • alveolar cells type 2: 6,003 nCPM
  • transitional alveolar cells: 5,447 nCPM
  • retinal bipolar cells: 3,841 nCPM
  • thyrotrophs: 2,544 nCPM
  • brain inhibitory neurons: 2,370 nCPM
  • corticotrophs: 2,219 nCPM

Immune cell

  • naive B-cell: 12 nTPM
  • memory B-cell: 8.7 nTPM
  • neutrophil: 3.6 nTPM
  • non-classical monocyte: 1.8 nTPM
  • intermediate monocyte: 1.3 nTPM
  • classical monocyte: 0.6 nTPM

Brain region

  • basal ganglia: 25 nTPM
  • hypothalamus: 22 nTPM
  • cerebral cortex: 17 nTPM
  • midbrain: 16 nTPM
  • white matter: 16 nTPM
  • hippocampal formation: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MACROD2.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 101 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.43
gnomAD missense Z
0.71
DepMap mean gene effect
0.22
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MACROD2 as an antibody target. Whether an autoantibody or antibody against MACROD2 could matter depends on whether native MACROD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MACROD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MACROD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MACROD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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