MACO1
Macoilin
Also known as: FLJ10747, MACOI_HUMAN, TMEM57
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N5G2
- Gene
- MACO1
- Ensembl
- ENSG00000204178
- Chromosome
- 1
- Canonical length
- 664 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Cytosol
OverviewNCBI Gene
Predicted to enable microtubule binding activity. Involved in neuronal signal transduction. Located in rough endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
664 residues, UniProt reviewed canonical sequence.
>Q8N5G2|MACO1
1 MKRRNADCSK LRRPLKRNRI TEGIYGSTFL YLKFLVVWAL VLLADFVLEF RFEYLWPFWL
61 FIRSVYDSFR YQGLAFSVFF VCVAFTSNII CLLFIPIQWL FFAASTYVWV QYVWHTERGV
121 CLPTVSLWIL FVYIEAAIRF KDLKNFHVDL CRPFAAHCIG YPVVTLGFGF KSYVSYKMRL
181 RKQKEVQKEN EFYMQLLQQA LPPEQQMLQK QEKEAEEAAK GLPDMDSSIL IHHNGGIPAN
241 KKLSTTLPEI EYREKGKEKD KDAKKHNLGI NNNNILQPVD SKIQEIEYME NHINSKRLNN
301 DLVGSTENLL KEDSCTASSK NYKNASGVVN SSPRSHSATN GSIPSSSSKN EKKQKCTSKS
361 PSTHKDLMEN CIPNNQLSKP DALVRLEQDI KKLKADLQAS RQVEQELRSQ ISSLSSTERG
421 IRSEMGQLRQ ENELLQNKLH NAVQMKQKDK QNISQLEKKL KAEQEARSFV EKQLMEEKKR
481 KKLEEATAAR AVAFAAASRG ECTETLRNRI RELEAEGKKL TMDMKVKEDQ IRELELKVQE
541 LRKYKENEKD TEVLMSALSA MQDKTQHLEN SLSAETRIKL DLFSALGDAK RQLEIAQGQI
601 LQKDQEIKDL KQKIAEVMAV MPSITYSAAT SPLSPVSPHY SSKFVETSPS GLDPNASVYQ
661 PLKKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MACO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 27 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 27 nTPM
- liver: 25 nTPM
- cerebellum: 24 nTPM
- skeletal muscle: 23 nTPM
- pancreas: 23 nTPM
- salivary gland: 15 nTPM
Single-cell type
- esophageal apical cells: 548 nCPM
- myonuclei: 227 nCPM
- thymic myoid cells: 219 nCPM
- pancreatic acinar cells: 190 nCPM
- erythrocyte progenitors: 181 nCPM
- hepatocytes: 154 nCPM
Immune cell
- eosinophil: 1.6 nTPM
- plasmacytoid DC: 1.1 nTPM
- naive CD8 T-cell: 0.7 nTPM
- basophil: 0.5 nTPM
- MAIT T-cell: 0.5 nTPM
- memory CD4 T-cell: 0.5 nTPM
Brain region
- cerebellum: 34 nTPM
- choroid plexus: 19 nTPM
- white matter: 18 nTPM
- cerebral cortex: 18 nTPM
- hypothalamus: 16 nTPM
- basal ganglia: 15 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.26
- gnomAD pLI
- 1
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Macoilin
- Macoilin family
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MACO1 as an antibody target. Whether an autoantibody or antibody against MACO1 could matter depends on whether native MACO1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MACO1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MACO1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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