Seroatlas · Human Serome Atlas

MAB21L4

Protein mab-21-like 4

Also known as: C2orf54, FLJ22671, MB214_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08AI8
Gene: MAB21L4
Ensembl: ENSG00000172478
Chromosome: 2
Canonical length: 447 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

No narrative summary is available for MAB21L4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

447 residues, UniProt reviewed canonical sequence.

>Q08AI8|MAB21L4
     1  MPAPALPTSA MAVQVPLWHH YLQAIRSREA PRAQDFQRAE NVLLTVLERV HALDPRFIVD
    61  YSRGLEAFQF ALRSSEDPMD MEVPLWVDAE ALLIEEPEAT QPEDGLELCH LGVPREGAGL
   121  ERWTTEDTFT ASSEGDAKCR GHIVPSKVLC VLKDLLVAAI VHCKHHSLIA PGSLNAASLR
   181  EEQLHLSLLV SSGWRTISFH VVPVVRRKLG APALEGVQQM PGFPEGSLRR ILSQGVDLVP
   241  ASAQLWRTST DYLLTRLLGE LGSLQGHRLD SLSILDRVNH ESWRDSGQTD GLTFGHLKMV
   301  LLWASVLFLA PEDWAELQGA VYRLLVVLLC CLATRKLPHF LHPQRNLLQG SGLDLGAIYQ
   361  RVEGFASQPE AALRIHATHL GRSPPPRIGS GLKALLQLPA SDPTYWATAY FDVLLDKFQV
   421  FNIQDKDRIS AMQSIFQKTR TLGGEES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAB21L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 190 nTPM

Expression across tissuesHPA

Tissue

esophagus: 190 nTPM
vagina: 58 nTPM
cervix: 56 nTPM
skin: 45 nTPM
tonsil: 22 nTPM
salivary gland: 19 nTPM

Single-cell type

esophageal apical cells: 1,388 nCPM
esophageal suprabasal cells: 187 nCPM
alveolar cells type 1: 103 nCPM
salivary duct cells: 79 nCPM
suprabasal keratinocytes: 69 nCPM
esophageal basal cells: 39 nCPM

Immune cell

NK-cell: 0.9 nTPM
eosinophil: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 8.6 nTPM
hippocampal formation: 7.6 nTPM
basal ganglia: 7 nTPM
cerebellum: 6.9 nTPM
amygdala: 6.6 nTPM
pons: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAB21L4 as an antibody target. Whether an autoantibody or antibody against MAB21L4 could matter depends on whether native MAB21L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAB21L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAB21L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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