MAB21L3
Protein mab-21-like 3
Also known as: C1orf161, FLJ38716, MB213_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N8X9
- Gene
- MAB21L3
- Ensembl
- ENSG00000173212
- Chromosome
- 1
- Canonical length
- 362 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
No narrative summary is available for MAB21L3 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
362 residues, UniProt reviewed canonical sequence.
>Q8N8X9|MAB21L3
1 MKYLTVGDLE DCLLNKVDLR RQQISQAVEE VQKVVHHLTT NISNQDIRFQ AVPYSDTYNE
61 NIKVLAPSQF LVTVPIKGLA GYREAREQHW RYYTLQGTRL PCPLRDPEGL QQWLEVEQFM
121 KSLWQWHETD VNIDGDIVPA KVLLVFRKLV ENAVRTCHLS GKVSLLGNRS AVWVAVETSA
181 YQVELELVPA VEIPTTWSKK ARWPRCLQRW PSQERVECIK SFGFNLLACS NYHWQLSFLR
241 AEQVLLEQLD EDGGCRRKCF QVMRHLKEDI WCPGNRPVIT SHHLQTVLFW TCEKYPHFKD
301 WQVFSKAFLR LVRKLHKCVS QHFLKHYFVR NSNLFQCTNP TELDTVAQKL ATFLKNPQIG
361 PPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against MAB21L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 14 nTPM
Expression across tissuesHPA
Tissue
- retina: 14 nTPM
- skin: 10 nTPM
- bone marrow: 8.8 nTPM
- esophagus: 7.6 nTPM
- testis: 4.1 nTPM
- kidney: 3 nTPM
Single-cell type
- salivary ionocytes: 120 nCPM
- esophageal apical cells: 89 nCPM
- epididymal clear cells: 45 nCPM
- neutrophils: 42 nCPM
- endometrial luminal cells: 39 nCPM
- respiratory ionocytes: 38 nCPM
Immune cell
- basophil: 2.9 nTPM
- neutrophil: 2.5 nTPM
- naive B-cell: 1.6 nTPM
- NK-cell: 1 nTPM
- plasmacytoid DC: 0.9 nTPM
- memory B-cell: 0.8 nTPM
Brain region
- cerebral cortex: 181 nTPM
- cerebellum: 177 nTPM
- white matter: 170 nTPM
- basal ganglia: 149 nTPM
- thalamus: 147 nTPM
- pons: 144 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.08
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.1
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads MAB21L3 as an antibody target. Whether an autoantibody or antibody against MAB21L3 could matter depends on whether native MAB21L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
MAB21L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label MAB21L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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