Seroatlas · Human Serome Atlas

LZIC

Protein LZIC

Also known as: LZIC_HUMAN, MGC15436

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WZA0
Gene: LZIC
Ensembl: ENSG00000162441
Chromosome: 1
Canonical length: 190 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable beta-catenin binding activity. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>Q8WZA0|LZIC
     1  MASRGKTETS KLKQNLEEQL DRLMQQLQDL EECREELDTD EYEETKKETL EQLSEFNDSL
    61  KKIMSGNMTL VDELSGMQLA IQAAISQAFK TPEVIRLFAK KQPGQLRTRL AEMDRDLMVG
   121  KLERDLYTQQ KVEILTALRK LGEKLTADDE AFLSANAGAI LSQFEKVSTD LGSGDKILAL
   181  ASFEVEKTKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LZIC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

testis: 63 nTPM
ovary: 30 nTPM
liver: 28 nTPM
spinal cord: 28 nTPM
thymus: 28 nTPM
heart muscle: 28 nTPM

Single-cell type

late primary spermatocytes: 346 nCPM
early spermatids: 286 nCPM
megakaryocytes: 204 nCPM
early primary spermatocytes: 177 nCPM
esophageal apical cells: 113 nCPM
oocytes: 101 nCPM

Immune cell

eosinophil: 40 nTPM
plasmacytoid DC: 38 nTPM
basophil: 35 nTPM
non-classical monocyte: 33 nTPM
intermediate monocyte: 30 nTPM
T-reg: 29 nTPM

Brain region

white matter: 44 nTPM
cerebellum: 38 nTPM
spinal cord: 37 nTPM
medulla oblongata: 37 nTPM
basal ganglia: 36 nTPM
midbrain: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: 0.84
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

response to ionizing radiation

Molecular functions

beta-catenin binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

InteractionsUniProt · HPA

Protein binding partners of LZIC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LZIC as an antibody target. Whether an autoantibody or antibody against LZIC could matter depends on whether native LZIC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LZIC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LZIC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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