Seroatlas · Human Serome Atlas

LYZL6

Lysozyme-like protein 6

Also known as: LYC1, LYZL6_HUMAN, PRO1485, TKAL754

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75951
Gene: LYZL6
Ensembl: ENSG00000275722
Chromosome: 17
Canonical length: 148 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

This gene encodes a member of the C-type lysozyme/alpha-lactalbumin family. C-type lysozymes are bacteriolytic factors that play a role in host defense, whereas alpha-lactalbumins mediate lactose biosynthesis. The encoded protein contains catalytic residues characteristic of C-type lysozymes and may play a role in male reproduction. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

148 residues, UniProt reviewed canonical sequence.

>O75951|LYZL6
     1  MTKALLIYLV SSFLALNQAS LISRCDLAQV LQLEDLDGFE GYSLSDWLCL AFVESKFNIS
    61  KINENADGSF DYGLFQINSH YWCNDYKSYS ENLCHVDCQD LLNPNLLAGI HCAKRIVSGA
   121  RGMNNWVEWR LHCSGRPLFY WLTGCRLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYZL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

testis: 44 nTPM
skin: 1 nTPM
retina: 0.3 nTPM
salivary gland: 0.2 nTPM
thyroid gland: 0.2 nTPM
heart muscle: 0.1 nTPM

Single-cell type

early spermatids: 271 nCPM
late primary spermatocytes: 183 nCPM
late spermatids: 40 nCPM
leydig cells: 0.5 nCPM
differentiating spermatogonia: 0.4 nCPM
epididymal efferent duct ciliated cells: 0.4 nCPM

Immune cell

eosinophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.7 nTPM
amygdala: 1.5 nTPM
basal ganglia: 1.5 nTPM
hippocampal formation: 1.5 nTPM
medulla oblongata: 1.4 nTPM
cerebellum: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

lysozyme activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYZL6 as an antibody target. Whether an autoantibody or antibody against LYZL6 could matter depends on whether native LYZL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYZL6 is annotated at the cell surface, where native LYZL6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LYZL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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