LYZL4
Lysozyme-like protein 4
Also known as: LYC4, LYZL4_HUMAN, MGC26768
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96KX0
- Gene
- LYZL4
- Ensembl
- ENSG00000157093
- Chromosome
- 3
- Canonical length
- 146 aa
- Protein class
- Predicted secreted proteins
- Subcellular location
- Principal piece,End piece
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL4 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]
Canonical amino-acid sequenceUniProt
146 residues, UniProt reviewed canonical sequence.
>Q96KX0|LYZL4
1 MKASVVLSLL GYLVVPSGAY ILGRCTVAKK LHDGGLDYFE GYSLENWVCL AYFESKFNPM
61 AIYENTREGY TGFGLFQMRG SDWCGDHGRN RCHMSCSALL NPNLEKTIKC AKTIVKGKEG
121 MGAWPTWSRY CQYSDTLARW LDGCKLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LYZL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.34
- Highest tissue expression
- 50 nTPM
Expression across tissuesHPA
Tissue
- testis: 50 nTPM
- retina: 1 nTPM
- cerebral cortex: 0.5 nTPM
- amygdala: 0.4 nTPM
- hippocampal formation: 0.2 nTPM
- basal ganglia: 0.1 nTPM
Single-cell type
- early spermatids: 375 nCPM
- late primary spermatocytes: 270 nCPM
- late spermatids: 196 nCPM
- sertoli cells: 3.6 nCPM
- ependymal cells: 1.5 nCPM
- peritubular myoid cells: 1.5 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 2.6 nTPM
- basal ganglia: 0.7 nTPM
- amygdala: 0.6 nTPM
- hippocampal formation: 0.6 nTPM
- white matter: 0.4 nTPM
- medulla oblongata: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.74
- gnomAD pLI
- 0.53
- gnomAD missense Z
- 0.5
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LYZL4 as an antibody target. Whether an autoantibody or antibody against LYZL4 could matter depends on whether native LYZL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LYZL4 is annotated as secreted, so native LYZL4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label LYZL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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