Seroatlas · Human Serome Atlas

LYSMD4

LysM and putative peptidoglycan-binding domain-containing protein 4

Also known as: FLJ33008, LYSM4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5XG99
Gene: LYSMD4
Ensembl: ENSG00000183060
Chromosome: 15
Canonical length: 296 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Actin filaments,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>Q5XG99|LYSMD4
     1  MRHEELLTKT FQGPAVVCGT PTSHVYMFKN GSGDSGDSSE EESHRVVLRP RGKERHKSGV
    61  HQPPQAGAGD VVLLQRELAQ EDSLNKLALQ YGCKVADIKK VNNFIREQDL YALKSVKIPV
   121  RNHGILMETH KELKPLLSPS SETTVTVELP EADRAGAGTG AQAGQLMGFF KGIDQDIERA
   181  VQSEIFLHES YCMDTSHQPL LPAPPKTPMD GADCGIQWWN AVFIMLLIGI VLPVFYLVYF
   241  KIQASGETPN SLNTTVIPNG SMAMGTVPGQ APRLAVAVPA VTSADSQFSQ TTQAGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYSMD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 17 nTPM
skin: 14 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 12 nTPM
amygdala: 12 nTPM
hippocampal formation: 11 nTPM

Single-cell type

cardiomyocytes: 72 nCPM
epicardial cells: 41 nCPM
oocytes: 37 nCPM
esophageal apical cells: 33 nCPM
salivary acinar cells: 26 nCPM
early primary spermatocytes: 26 nCPM

Immune cell

eosinophil: 4.4 nTPM
naive CD4 T-cell: 2.8 nTPM
plasmacytoid DC: 2.6 nTPM
T-reg: 2.5 nTPM
memory CD4 T-cell: 2.3 nTPM
memory CD8 T-cell: 2.3 nTPM

Brain region

cerebral cortex: 6.6 nTPM
thalamus: 6.4 nTPM
white matter: 6.1 nTPM
midbrain: 5.5 nTPM
cerebellum: 5.3 nTPM
basal ganglia: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYSMD4 as an antibody target. Whether an autoantibody or antibody against LYSMD4 could matter depends on whether native LYSMD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYSMD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LYSMD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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