Seroatlas · Human Serome Atlas

LYSET

Lysosomal enzyme trafficking factor

Also known as: C14orf109, DKFZP564F1123, LYSET_HUMAN, TMEM251

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6I4
Gene: LYSET
Ensembl: ENSG00000153485
Chromosome: 14
Canonical length: 163 aa
Protein class: Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Cell Junctions

OverviewNCBI Gene

Involved in lysosomal transport; lysosome organization; and regulation of vesicle-mediated transport. Located in Golgi cisterna. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>Q8N6I4|LYSET
     1  MPKPPDYSEL SDSLTLAVGT GRFSGPLHRA WRMMNFRQRM GWIGVGLYLL ASAAAFYYVF
    61  EISETYNRLA LEHIQQHPEE PLEGTTWTHS LKAQLLSLPF WVWTVIFLVP YLQMFLFLYS
   121  CTRADPKTVG YCIIPICLAV ICNRHQAFVK ASNQISRLQL IDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYSET can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

kidney: 32 nTPM
skeletal muscle: 29 nTPM
prostate: 25 nTPM
heart muscle: 24 nTPM
colon: 22 nTPM
adrenal gland: 22 nTPM

Single-cell type

medullary thymic epithelial cells: 2.4 nCPM
gastric chief cells: 2.2 nCPM
melanocytes: 2.2 nCPM
parietal cells: 1.8 nCPM
breast myoepithelial cells: 0.9 nCPM
undifferentiated spermatogonia: 0.8 nCPM

Immune cell

eosinophil: 14 nTPM
non-classical monocyte: 13 nTPM
neutrophil: 11 nTPM
classical monocyte: 10 nTPM
intermediate monocyte: 9.6 nTPM
myeloid DC: 8.4 nTPM

Brain region

white matter: 91 nTPM
cerebral cortex: 65 nTPM
pons: 59 nTPM
hippocampal formation: 52 nTPM
hypothalamus: 51 nTPM
amygdala: 45 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LYSET.

Disease | AllUniProt

Conditions LYSET is implicated in, by any mechanism.

Dysostosis multiplex, Ain-Naz type (DMAN) MIM:619345

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 31 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Dysostosis multiplex, Ain-Naz type
Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0.01
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Lysosomal enzyme trafficking factor
Transmembrane protein 251

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LYSET in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYSET as an antibody target. Whether an autoantibody or antibody against LYSET could matter depends on whether native LYSET is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYSET is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LYSET as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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