Seroatlas · Human Serome Atlas

LYPLAL1

Lysophospholipase-like protein 1

Also known as: LYPL1_HUMAN, Q96AV0

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VWZ2
Gene: LYPLAL1
Ensembl: ENSG00000143353
Chromosome: 1
Canonical length: 237 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables palmitoyl-(protein) hydrolase activity. Involved in negative regulation of cGAS/STING signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

237 residues, UniProt reviewed canonical sequence.

>Q5VWZ2|LYPLAL1
     1  MAAASGSVLQ RCIVSPAGRH SASLIFLHGS GDSGQGLRMW IKQVLNQDLT FQHIKIIYPT
    61  APPRSYTPMK GGISNVWFDR FKITNDCPEH LESIDVMCQV LTDLIDEEVK SGIKKNRILI
   121  GGFSMGGCMA IHLAYRNHQD VAGVFALSSF LNKASAVYQA LQKSNGVLPE LFQCHGTADE
   181  LVLHSWAEET NSMLKSLGVT TKFHSFPNVY HELSKTELDI LKLWILTKLP GEMEKQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYPLAL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

kidney: 40 nTPM
heart muscle: 34 nTPM
liver: 26 nTPM
adrenal gland: 17 nTPM
spinal cord: 16 nTPM
thyroid gland: 15 nTPM

Single-cell type

choroid plexus epithelial cells: 476 nCPM
myonuclei: 258 nCPM
platelets: 248 nCPM
adrenal cortex cells: 242 nCPM
retinal pigment epithelial cells: 239 nCPM
distal convoluted tubule cells: 206 nCPM

Immune cell

memory B-cell: 3.3 nTPM
naive CD4 T-cell: 2.3 nTPM
neutrophil: 2.2 nTPM
classical monocyte: 2 nTPM
naive B-cell: 2 nTPM
MAIT T-cell: 1.9 nTPM

Brain region

white matter: 7.2 nTPM
hypothalamus: 6.5 nTPM
spinal cord: 5.4 nTPM
medulla oblongata: 5.2 nTPM
cerebellum: 5 nTPM
basal ganglia: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: -1.23
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYPLAL1 as an antibody target. Whether an autoantibody or antibody against LYPLAL1 could matter depends on whether native LYPLAL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYPLAL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LYPLAL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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