Seroatlas · Human Serome Atlas

LYPLA2

Acyl-protein thioesterase 2

Also known as: APT-2, LYPA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95372
Gene: LYPLA2
Ensembl: ENSG00000011009
Chromosome: 1
Canonical length: 231 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

231 residues, UniProt reviewed canonical sequence.

>O95372|LYPLA2
     1  MCGNTMSVPL LTDAATVSGA ERETAAVIFL HGLGDTGHSW ADALSTIRLP HVKYICPHAP
    61  RIPVTLNMKM VMPSWFDLMG LSPDAPEDEA GIKKAAENIK ALIEHEMKNG IPANRIVLGG
   121  FSQGGALSLY TALTCPHPLA GIVALSCWLP LHRAFPQAAN GSAKDLAILQ CHGELDPMVP
   181  VRFGALTAEK LRSVVTPARV QFKTYPGVMH SSCPQEMAAV KEFLEKLLPP V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYPLA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 176 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 176 nTPM
liver: 85 nTPM
kidney: 81 nTPM
esophagus: 78 nTPM
parathyroid gland: 73 nTPM
spleen: 61 nTPM

Single-cell type

epididymal efferent duct ciliated cells: 100 nCPM
esophageal apical cells: 94 nCPM
migrating cytotrophoblasts: 80 nCPM
cytotrophoblasts: 78 nCPM
extravillous trophoblasts: 78 nCPM
syncytiotrophoblasts: 78 nCPM

Immune cell

eosinophil: 125 nTPM
neutrophil: 114 nTPM
total PBMC: 114 nTPM
gdT-cell: 106 nTPM
intermediate monocyte: 96 nTPM
classical monocyte: 95 nTPM

Brain region

choroid plexus: 142 nTPM
hippocampal formation: 53 nTPM
cerebral cortex: 39 nTPM
thalamus: 38 nTPM
basal ganglia: 38 nTPM
midbrain: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.95
gnomAD missense Z: 1.7
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYPLA2 as an antibody target. Whether an autoantibody or antibody against LYPLA2 could matter depends on whether native LYPLA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYPLA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LYPLA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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