LYPD8
Ly6/PLAUR domain-containing protein 8
Also known as: LYPD8_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UX82
- Gene
- LYPD8
- Ensembl
- ENSG00000259823
- Chromosome
- 1
- Canonical length
- 237 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to digestive system
OverviewNCBI Gene
Predicted to be involved in defense response to Gram-negative bacterium. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
237 residues, UniProt reviewed canonical sequence.
>Q6UX82|LYPD8
1 MKGILVAGIT AVLVAAVESL SCVQCNSWEK SCVNSIASEC PSHANTSCIS SSASSSLETP
61 VRLYQNMFCS AENCSEETHI TAFTVHVSAE EHFHFVSQCC QGKECSNTSD ALDPPLKNVS
121 SNAECPACYE SNGTSCHGKP WKCYEEEQCV FLVAELKNDI ESKSLVLKGC SNVSNATCQF
181 LSGENKTLGG VIFRKFECAN VNSLTPTSAP TTSHNVGSKA SLYLLALASL LLRGLLPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LYPD8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 203 nTPM
Expression across tissuesHPA
Tissue
- colon: 203 nTPM
- rectum: 119 nTPM
- small intestine: 25 nTPM
- appendix: 11 nTPM
- smooth muscle: 3.3 nTPM
- cerebral cortex: 2.4 nTPM
Single-cell type
- colonocytes: 21 nCPM
- goblet cells: 9.6 nCPM
- proximal tubule cells: 4.5 nCPM
- loop of henle epithelial cells: 3.9 nCPM
- distal convoluted tubule cells: 2.9 nCPM
- enterocytes: 2.3 nCPM
Immune cell
- plasmacytoid DC: 0.9 nTPM
- neutrophil: 0.6 nTPM
- MAIT T-cell: 0.4 nTPM
- intermediate monocyte: 0.3 nTPM
- classical monocyte: 0.2 nTPM
- basophil: 0 nTPM
Brain region
- cerebral cortex: 4.2 nTPM
- amygdala: 3.1 nTPM
- white matter: 2.9 nTPM
- basal ganglia: 2.7 nTPM
- hippocampal formation: 2.3 nTPM
- thalamus: 0.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- 0.57
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LYPD8 as an antibody target. Whether an autoantibody or antibody against LYPD8 could matter depends on whether native LYPD8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LYPD8 is annotated at the cell surface, where native LYPD8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label LYPD8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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