Seroatlas · Human Serome Atlas

LYPD6B

Ly6/PLAUR domain-containing protein 6B

Also known as: CT116, LPD6B_HUMAN, LYPD7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NI32
Gene
LYPD6B
Ensembl
ENSG00000150556
Chromosome
2
Canonical length
183 aa
Protein class
Predicted intracellular proteins, Transporters
Secretome location
Intracellular and membrane

OverviewNCBI Gene

Enables acetylcholine receptor regulator activity. Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q8NI32|LYPD6B
     1  MLYKSSDRPA HKVSMLLLCH ALAIAVVQIV IFSESWAFAK NINFYNVRPP LDPTPFPNSF
    61  KCFTCENAGD NYNCNRWAED KWCPQNTQYC LTVHHFTSHG RSTSITKKCA SRSECHFVGC
   121  HHSRDSEHTE CRSCCEGMIC NVELPTNHTN AVFAVMHAQR TSGSSAPTLY LPVLAWVFVL
   181  PLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYPD6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
92 nTPM

Expression across tissuesHPA

Tissue

  • skin: 92 nTPM
  • stomach: 39 nTPM
  • gallbladder: 35 nTPM
  • testis: 33 nTPM
  • fallopian tube: 22 nTPM
  • kidney: 21 nTPM

Single-cell type

  • foveolar cells: 665 nCPM
  • prostatic club cells: 494 nCPM
  • papillary tip epithelial cells: 369 nCPM
  • urothelial cells: 326 nCPM
  • renal collecting duct principal cells: 302 nCPM
  • prostatic hillock cells: 283 nCPM

Immune cell

  • basophil: 14 nTPM
  • naive B-cell: 3.1 nTPM
  • memory B-cell: 2.8 nTPM
  • total PBMC: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • thalamus: 14 nTPM
  • midbrain: 13 nTPM
  • cerebral cortex: 8.8 nTPM
  • hippocampal formation: 6.5 nTPM
  • hypothalamus: 6.3 nTPM
  • amygdala: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.65
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYPD6B as an antibody target. Whether an autoantibody or antibody against LYPD6B could matter depends on whether native LYPD6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYPD6B is annotated at the cell surface, where native LYPD6B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LYPD6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LYPD6B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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