Seroatlas · Human Serome Atlas

LYPD5

Ly6/PLAUR domain-containing protein 5

Also known as: FLJ30469, LYPD5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWN5
Gene: LYPD5
Ensembl: ENSG00000159871
Chromosome: 19
Canonical length: 251 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

251 residues, UniProt reviewed canonical sequence.

>Q6UWN5|LYPD5
     1  MAMGVPRVIL LCLFGAALCL TGSQALQCYS FEHTYFGPFD LRAMKLPSIS CPHECFEAIL
    61  SLDTGYRAPV TLVRKGCWTG PPAGQTQSNA DALPPDYSVV RGCTTDKCNA HLMTHDALPN
   121  LSQAPDPPTL SGAECYACIG VHQDDCAIGR SRRVQCHQDQ TACFQGNGRM TVGNFSVPVY
   181  IRTCHRPSCT TEGTTSPWTA IDLQGSCCEG YLCNRKSMTQ PFTSASATTP PRALQVLALL
   241  LPVLLLVGLS A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYPD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

skin: 48 nTPM
cervix: 11 nTPM
esophagus: 11 nTPM
vagina: 8.1 nTPM
cerebral cortex: 5.5 nTPM
spleen: 4.5 nTPM

Single-cell type

late spermatids: 159 nCPM
esophageal apical cells: 130 nCPM
late primary spermatocytes: 52 nCPM
early spermatids: 37 nCPM
syncytiotrophoblasts: 36 nCPM
brain inhibitory neurons: 23 nCPM

Immune cell

intermediate monocyte: 0.9 nTPM
classical monocyte: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
non-classical monocyte: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
neutrophil: 0.1 nTPM

Brain region

pons: 17 nTPM
cerebral cortex: 15 nTPM
thalamus: 12 nTPM
medulla oblongata: 11 nTPM
white matter: 11 nTPM
midbrain: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYPD5 as an antibody target. Whether an autoantibody or antibody against LYPD5 could matter depends on whether native LYPD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYPD5 is annotated at the cell surface, where native LYPD5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LYPD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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