Seroatlas · Human Serome Atlas

LYPD4

Ly6/PLAUR domain-containing protein 4

Also known as: LYPD4_HUMAN, MGC42718

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWN0
Gene: LYPD4
Ensembl: ENSG00000273111
Chromosome: 19
Canonical length: 246 aa
Protein class: Predicted intracellular proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to be located in extracellular region and plasma membrane. Predicted to be active in plasma membrane raft. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>Q6UWN0|LYPD4
     1  MGPQHLRLVQ LFCLLGAIST LPRAGALLCY EATASRFRAV AFHNWKWLLM RNMVCKLQEG
    61  CEETLVFIET GTARGVVGFK GCSSSSSYPA QISYLVSPPG VSIASYSRVC RSYLCNNLTN
   121  LEPFVKLKAS TPKSITSASC SCPTCVGEHM KDCLPNFVTT NSCPLAASTC YSSTLKFQAG
   181  FLNTTFLLMG CAREHNQLLA DFHHIGSIKV TEVLNILEKS QIVGAASSRQ DPAWGVVLGL
   241  LFAFRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYPD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

testis: 100 nTPM
bone marrow: 0.3 nTPM
esophagus: 0.1 nTPM
skeletal muscle: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 1,506 nCPM
late primary spermatocytes: 623 nCPM
early spermatids: 247 nCPM
early primary spermatocytes: 92 nCPM
sertoli cells: 5.3 nCPM
undifferentiated spermatogonia: 2.8 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

basal ganglia: 0.5 nTPM
cerebral cortex: 0.4 nTPM
choroid plexus: 0.4 nTPM
hypothalamus: 0.4 nTPM
pons: 0.4 nTPM
thalamus: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: -0.15
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

binding of sperm to zona pellucida
sperm migration through the uterotubal junction

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYPD4 as an antibody target. Whether an autoantibody or antibody against LYPD4 could matter depends on whether native LYPD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYPD4 is annotated at the cell surface, where native LYPD4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LYPD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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