LYPD2
Ly6/PLAUR domain-containing protein 2
Also known as: LYPD2_HUMAN, LYPDC2, RGTR430, UNQ430
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UXB3
- Gene
- LYPD2
- Ensembl
- ENSG00000197353
- Chromosome
- 8
- Canonical length
- 125 aa
- Protein class
- Predicted intracellular proteins
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Predicted to be located in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
125 residues, UniProt reviewed canonical sequence.
>Q6UXB3|LYPD2
1 MRGTRLALLA LVLAACGELA PALRCYVCPE PTGVSDCVTI ATCTTNETMC KTTLYSREIV
61 YPFQGDSTVT KSCASKCKPS DVDGIGQTLP VSCCNTELCN VDGAPALNSL HCGALTLLPL
121 LSLRLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LYPD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 339 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 339 nTPM
- vagina: 44 nTPM
- cervix: 39 nTPM
- skin: 28 nTPM
- tonsil: 25 nTPM
- salivary gland: 24 nTPM
Single-cell type
- esophageal apical cells: 18,672 nCPM
- conjunctival goblet cells: 2,628 nCPM
- ocular epithelial cells: 364 nCPM
- respiratory deuterosomal cells: 149 nCPM
- respiratory secretory cells: 126 nCPM
- gastric progenitor cells: 126 nCPM
Immune cell
- non-classical monocyte: 442 nTPM
- intermediate monocyte: 34 nTPM
- myeloid DC: 20 nTPM
- total PBMC: 10 nTPM
- memory B-cell: 2 nTPM
- plasmacytoid DC: 1.6 nTPM
Brain region
- cerebral cortex: 1.1 nTPM
- cerebellum: 0.7 nTPM
- basal ganglia: 0.5 nTPM
- hippocampal formation: 0.5 nTPM
- thalamus: 0.5 nTPM
- medulla oblongata: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.33
- gnomAD pLI
- 0.25
- gnomAD missense Z
- 0.2
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LYPD2 as an antibody target. Whether an autoantibody or antibody against LYPD2 could matter depends on whether native LYPD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LYPD2 is annotated at the cell surface, where native LYPD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label LYPD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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