Seroatlas · Human Serome Atlas

LYL1

Protein lyl-1

Also known as: bHLHa18, LYL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P12980
Gene: LYL1
Ensembl: ENSG00000104903
Chromosome: 19
Canonical length: 280 aa
Protein class: Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>P12980|LYL1
     1  MCPPQAQAEV GPTMTEKAEM VCAPSPAPAP PPKPASPGPP QVEEVGHRGG SSPPRLPPGV
    61  PVISLGHSRP PGVAMPTTEL GTLRPPLLQL STLGTAPPTL ALHYHPHPFL NSVYIGPAGP
   121  FSIFPSSRLK RRPSHCELDL AEGHQPQKVA RRVFTNSRER WRQQNVNGAF AELRKLLPTH
   181  PPDRKLSKNE VLRLAMKYIG FLVRLLRDQA AALAAGPTPP GPRKRPVHRV PDDGARRGSG
   241  RRAEAAARSQ PAPPADPDGS PGGAARPIKM EQTALSPEVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LYL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

spleen: 35 nTPM
bone marrow: 34 nTPM
testis: 20 nTPM
small intestine: 13 nTPM
lung: 12 nTPM
lymph node: 12 nTPM

Single-cell type

late spermatids: 1,265 nCPM
platelets: 697 nCPM
megakaryocytes: 501 nCPM
early spermatids: 366 nCPM
late primary spermatocytes: 299 nCPM
hofbauer cells: 200 nCPM

Immune cell

eosinophil: 6.4 nTPM
naive B-cell: 3.7 nTPM
non-classical monocyte: 2.8 nTPM
basophil: 2.4 nTPM
neutrophil: 2.4 nTPM
memory B-cell: 2.1 nTPM

Brain region

white matter: 16 nTPM
spinal cord: 15 nTPM
thalamus: 15 nTPM
medulla oblongata: 15 nTPM
pons: 13 nTPM
cerebellum: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.77
gnomAD missense Z: 0.95
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LYL1 as an antibody target. Whether an autoantibody or antibody against LYL1 could matter depends on whether native LYL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LYL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LYL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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