Seroatlas · Human Serome Atlas

LY86

Lymphocyte antigen 86

Also known as: dJ80N2.1, LY86_HUMAN, MD-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95711
Gene: LY86
Ensembl: ENSG00000112799
Chromosome: 6
Canonical length: 162 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

162 residues, UniProt reviewed canonical sequence.

>O95711|LY86
     1  MKGFTATLFL WTLIFPSCSG GGGGKAWPTH VVCSDSGLEV LYQSCDPLQD FGFSVEKCSK
    61  QLKSNINIRF GIILREDIKE LFLDLALMSQ GSSVLNFSYP ICEAALPKFS FCGRRKGEQI
   121  YYAGPVNNPE FTIPQGEYQV LLELYTEKRS TVACANATIM CS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LY86 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

tonsil: 73 nTPM
lymph node: 67 nTPM
spleen: 67 nTPM
appendix: 29 nTPM
lung: 28 nTPM
spinal cord: 28 nTPM

Single-cell type

microglia: 605 nCPM
hofbauer cells: 230 nCPM
b-cells: 225 nCPM
kupffer cells: 223 nCPM
cdc: 163 nCPM
monocytes: 146 nCPM

Immune cell

classical monocyte: 428 nTPM
myeloid DC: 427 nTPM
memory B-cell: 336 nTPM
naive B-cell: 250 nTPM
intermediate monocyte: 235 nTPM
total PBMC: 221 nTPM

Brain region

white matter: 31 nTPM
medulla oblongata: 17 nTPM
thalamus: 16 nTPM
spinal cord: 15 nTPM
hypothalamus: 12 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: -0.34
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LY86 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CD180

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LY86 as an antibody target. Whether an autoantibody or antibody against LY86 could matter depends on whether native LY86 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LY86 is annotated as secreted, so native LY86 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LY86 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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