Seroatlas · Human Serome Atlas

LY6S

Lymphocyte antigen 6S

Also known as: LY6S_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DTL4
Gene
LY6S
Canonical length
134 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for LY6S in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>P0DTL4|LY6S
     1  MSSLQAMKTL SLVLLVALLS MERAQGLRCY RCLAVLEGAS CSVVSCPFLD GVCVSQKVSV
    61  FGSKVRGENK LSLLSCQKDV GFPLLKLTSA VVDSQISCCK GDLCNAVVLA ASSPWALCVQ
   121  LLLSLGSVFL WALL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LY6S can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
1.7 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 1.7 nTPM
  • adrenal gland: 1.5 nTPM
  • gallbladder: 1.2 nTPM
  • thyroid gland: 1.2 nTPM
  • cerebral cortex: 0.9 nTPM
  • endometrium: 0.7 nTPM

Single-cell type

  • late spermatids: 2.5 nCPM
  • early spermatids: 0.6 nCPM
  • late primary spermatocytes: 0.6 nCPM
  • cardiomyocytes: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM

Immune cell

  • intermediate monocyte: 0.4 nTPM
  • classical monocyte: 0.2 nTPM
  • memory B-cell: 0.2 nTPM
  • myeloid DC: 0.2 nTPM
  • NK-cell: 0.2 nTPM
  • non-classical monocyte: 0.2 nTPM

Brain region

  • thalamus: 9.1 nTPM
  • cerebral cortex: 8 nTPM
  • cerebellum: 6.4 nTPM
  • midbrain: 6.1 nTPM
  • basal ganglia: 5.5 nTPM
  • hypothalamus: 5.5 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LY6S as an antibody target. Whether an autoantibody or antibody against LY6S could matter depends on whether native LY6S is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LY6S is annotated at the cell surface, where native LY6S is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LY6S as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LY6S. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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