Seroatlas · Human Serome Atlas

LY6L

Lymphocyte antigen 6L

Also known as: LY6L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
H3BQJ8
Gene
LY6L
Ensembl
ENSG00000261667
Chromosome
8
Canonical length
138 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be located in side of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

138 residues, UniProt reviewed canonical sequence.

>H3BQJ8|LY6L
     1  MERLVLTLCT LPLAVASAGC ATTPARNLSC YQCFKVSSWT ECPPTWCSPL DQVCISNEVV
    61  VSFKWSVRVL LSKRCAPRCP NDNMKFEWSP APMVQGVITR RCCSWALCNR ALTPQEGRWA
   121  LRGGLLLQVG LSLLRALL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LY6L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
5.8 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 5.8 nTPM
  • kidney: 2.2 nTPM
  • seminal vesicle: 0.3 nTPM
  • prostate: 0.1 nTPM
  • testis: 0.1 nTPM
  • thymus: 0.1 nTPM

Single-cell type

  • respiratory ionocytes: 10 nCPM
  • epididymal clear cells: 2 nCPM
  • prostatic club cells: 1.8 nCPM
  • epididymal principal cells: 1.2 nCPM
  • mesothelial cells: 0.9 nCPM
  • lymphatic endothelial cells: 0.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 5.1 nTPM
  • midbrain: 1.6 nTPM
  • amygdala: 1.3 nTPM
  • hypothalamus: 0.8 nTPM
  • cerebral cortex: 0.3 nTPM
  • basal ganglia: 0.2 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LY6L as an antibody target. Whether an autoantibody or antibody against LY6L could matter depends on whether native LY6L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LY6L is annotated at the cell surface, where native LY6L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LY6L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LY6L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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