LY6H
Lymphocyte antigen 6H
Also known as: LY6H_HUMAN, NMLY6
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O94772
- Gene
- LY6H
- Ensembl
- ENSG00000176956
- Chromosome
- 8
- Canonical length
- 140 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
140 residues, UniProt reviewed canonical sequence.
>O94772|LY6H
1 MLPAAMKGLG LALLAVLLCS APAHGLWCQD CTLTTNSSHC TPKQCQPSDT VCASVRITDP
61 SSSRKDHSVN KMCASSCDFV KRHFFSDYLM GFINSGILKV DVDCCEKDLC NGAAGAGHSP
121 WALAGGLLLS LGPALLWAGPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LY6H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 421 nTPM
Expression across tissuesHPA
Tissue
- hippocampal formation: 421 nTPM
- hypothalamus: 369 nTPM
- amygdala: 330 nTPM
- cerebral cortex: 317 nTPM
- basal ganglia: 171 nTPM
- midbrain: 71 nTPM
Single-cell type
- other brain neurons: 217 nCPM
- brain inhibitory neurons: 96 nCPM
- brain excitatory neurons: 82 nCPM
- oligodendrocyte progenitor cells: 50 nCPM
- ependymal cells: 27 nCPM
- oligodendrocytes: 13 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 170 nTPM
- hippocampal formation: 140 nTPM
- cerebral cortex: 124 nTPM
- basal ganglia: 100 nTPM
- amygdala: 68 nTPM
- midbrain: 56 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1
- gnomAD pLI
- 0.17
- gnomAD missense Z
- 0.61
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of LY6H in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LY6H as an antibody target. Whether an autoantibody or antibody against LY6H could matter depends on whether native LY6H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LY6H is annotated at the cell surface, where native LY6H is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label LY6H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...