Seroatlas · Human Serome Atlas

LY6G6F

Lymphocyte antigen 6 complex locus protein G6f

Also known as: C6orf21, G6f, LY66F_HUMAN, LY6G6D, NG32

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SQ64
Gene: LY6G6F
Ensembl: ENSG00000204424
Chromosome: 6
Canonical length: 297 aa
Protein class: Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The human G6f protein is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, which is comprised of cell-surface proteins involved in the immune system and cellular recognition (de Vet et al., 2003 [PubMed 12852788]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>Q5SQ64|LY6G6F
     1  MAVLFLLLFL CGTPQAADNM QAIYVALGEA VELPCPSPPT LHGDEHLSWF CSPAAGSFTT
    61  LVAQVQVGRP APDPGKPGRE SRLRLLGNYS LWLEGSKEED AGRYWCAVLG QHHNYQNWRV
   121  YDVLVLKGSQ LSARAADGSP CNVLLCSVVP SRRMDSVTWQ EGKGPVRGRV QSFWGSEAAL
   181  LLVCPGEGLS EPRSRRPRII RCLMTHNKGV SFSLAASIDA SPALCAPSTG WDMPWILMLL
   241  LTMGQGVVIL ALSIVLWRQR VRGAPGRDAS IPQFKPEIQV YENIHLARLG PPAHKPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LY6G6F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 3.6 nTPM
skin: 1.3 nTPM
spleen: 1.2 nTPM
lung: 0.9 nTPM
choroid plexus: 0.3 nTPM
testis: 0.3 nTPM

Single-cell type

platelets: 519 nCPM
megakaryocytes: 80 nCPM
megakaryocyte progenitors: 8.3 nCPM
late spermatids: 1.4 nCPM
kupffer cells: 1 nCPM
pdcs: 0.7 nCPM

Immune cell

total PBMC: 17 nTPM
neutrophil: 2.6 nTPM
plasmacytoid DC: 0.5 nTPM
eosinophil: 0.4 nTPM
intermediate monocyte: 0.4 nTPM
classical monocyte: 0.2 nTPM

Brain region

cerebral cortex: 0.3 nTPM
basal ganglia: 0.2 nTPM
amygdala: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.68

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LY6G6F in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LY6G6F as an antibody target. Whether an autoantibody or antibody against LY6G6F could matter depends on whether native LY6G6F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LY6G6F is annotated at the cell surface, where native LY6G6F is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LY6G6F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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